User profiles for M. Thangaraju
Muthusamy ThangarajuAssociate Professor of Biochemistry and Molecular Biology, Augusta University Verified email at gru.edu Cited by 11147 |
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond
Tumor cells have an increased demand for nutrients; this demand is met by increased
availability of nutrients through vasculogenesis and by enhanced cellular entry of nutrients …
availability of nutrients through vasculogenesis and by enhanced cellular entry of nutrients …
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host
… The relative proportions of these three bacterial metabolites in the colonic lumen are 6:3:1,
and the total concentration is approximately 100 mm. These metabolites are readily absorbed …
and the total concentration is approximately 100 mm. These metabolites are readily absorbed …
[HTML][HTML] Sodium-coupled monocarboxylate transporters in normal tissues and in cancer
SLC5A8 and SLC5A12 are sodium-coupled monocarboxylate transporters (SMCTs), the
former being a high-affinity type and the latter a low-affinity type. Both transport a variety of …
former being a high-affinity type and the latter a low-affinity type. Both transport a variety of …
[PDF][PDF] Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
Commensal gut microflora and dietary fiber protect against colonic inflammation and colon
cancer through unknown targets. Butyrate, a bacterial product from fermentation of dietary …
cancer through unknown targets. Butyrate, a bacterial product from fermentation of dietary …
GPR109A is a G-protein–coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
Short-chain fatty acids, generated in colon by bacterial fermentation of dietary fiber, protect
against colorectal cancer and inflammatory bowel disease. Among these bacterial metabolites…
against colorectal cancer and inflammatory bowel disease. Among these bacterial metabolites…
Solubilization of zinc compounds by the diazotrophic, plant growth promoting bacterium Gluconacetobacter diazotrophicus
VS Saravanan, M Madhaiyan, M Thangaraju - Chemosphere, 2007 - Elsevier
Gluconacetobacter diazotrophicus an endophytic diazotroph also encountered as rhizosphere
bacterium is reported to possess different plant growth promoting characteristics. In this …
bacterium is reported to possess different plant growth promoting characteristics. In this …
[HTML][HTML] Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
…, I Asm, A Chadli, KA Hassan, M Thangaraju… - Nature …, 2017 - nature.com
It is widely accepted that dynamic and reversible tumour cell plasticity is required for
metastasis, however, in vivo steps and molecular mechanisms are poorly elucidated. We …
metastasis, however, in vivo steps and molecular mechanisms are poorly elucidated. We …
Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells
Butyrate, an intestinal microbiota metabolite of dietary fiber, has been shown to exhibit
protective effects toward inflammatory diseases such as ulcerative colitis (UC) and inflammation-…
protective effects toward inflammatory diseases such as ulcerative colitis (UC) and inflammation-…
[HTML][HTML] Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of …
Mammalian colon harbors trillions of bacteria, yet there is no undue inflammatory response
by the host against these bacteria under normal conditions. The bacterial fermentation …
by the host against these bacteria under normal conditions. The bacterial fermentation …
Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.
U Kumar, R Sasi, S Suresh, A Patel, M Thangaraju… - …, 1999 - Am Diabetes Assoc
We have developed a panel of rabbit polyclonal antipeptide antibodies against the five
human somatostatin receptor subtypes (hSSTR1-5) and used them to analyze the pattern of …
human somatostatin receptor subtypes (hSSTR1-5) and used them to analyze the pattern of …