ATP-sensitive K+ channels in pancreatic, cardiac, and vascular smooth muscle cells

H Yokoshiki, M Sunagawa, T Seki… - American Journal of …, 1998 - journals.physiology.org
ATP-sensitive K + (K ATP ) channels are therapeutic targets for several diseases, including
angina, hypertension, and diabetes. This is because stimulation of K ATP channels is thought …

Levosimendan, a novel Ca2+ sensitizer, activates the glibenclamide-sensitive K+ channel in rat arterial myocytes

H Yokoshiki, Y Katsube, M Sunagawa… - European journal of …, 1997 - Elsevier
The electrophysiological effect of levosimendan, a novel Ca 2+ -sensitizing positive inotropic
agent and vasodilator, was examined on rat mesenteric arterial myocytes using the patch …

Cholinergic signaling via muscarinic receptors directly and indirectly suppresses pancreatic tumorigenesis and cancer stemness

…, M Sunagawa, R Takahashi, Z Jiang, M Macchini… - Cancer discovery, 2018 - AACR
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been
shown to modulate tumor growth. However, whether cholinergic signaling directly regulates …

Thoracic esophageal diverticula: why is operation necessary?

NK Altorki, M Sunagawa, DB Skinner - The Journal of thoracic and …, 1993 - Elsevier
Diverticula of the thoracic esophagus are uncommon disorders. The indications for surgical
intervention in asymptomatic or minimally symptomatic patients are unclear. Among 20 …

Complications after cyst excision with hepaticoenterostomy for choledochal cysts and their surgical management in children versus adults

…, Y Hosoda, T Fujiwara, S Kohno, M Sunagawa… - Journal of pediatric …, 1997 - Elsevier
… The type of choledochal cysts m the present study were &her type I (no IHBD chlatation)
or type IV-A (association with IHBD dilatation) according to the Todani’s classificatlorx9 Data …

Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I

…, T Okuda, H Matsumura, M Sunagawa - Antimicrobial agents …, 1992 - Am Soc Microbiol
The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied
extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was …

The novel calcium sensitizer levosimendan activates the ATP-sensitive K+ channel in rat ventricular cells

H Yokoshiki, Y Katsube, M Sunagawa… - Journal of Pharmacology …, 1997 - ASPET
Levosimendan, a new Ca ++ -sensitizing and positive inotropic agent, was reported to act as
a coronary vasodilator and protect ischemic myocardium. To elucidate the mechanisms of …

Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α …

…, Y Zhang, Y Qian, H Zhang, S Guo, M Sunagawa… - Molecular …, 2013 - Elsevier
… The free DNA and DNA–protein mixtures were resolved on 5% native polyacrylamide gels
in 0.5× TBE buffer (0.4 M Tris, 0.45 M boric acid, 0.5 M EDTA, pH 8.0) by electrophoresis for …

A novel carbapenem antibiotic, SM-7338 structure-activity relationships

M Sunagawa, H MATSUMURA, T INOUE… - The journal of …, 1990 - jstage.jst.go.jp
Wehave studied on the synthesis of a variety of carbapenem derivatives and found that the
carbapenem compounds having 5'-aminocarbonyl pyrrolidin-3'-ylthio group as C-2 side …

[PDF][PDF] RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis

…, Y Kumagai, M Sunagawa, M Tominaga… - Cell, 2020 - cell.com
Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-hydroxytryptamine
[5-HT]) production. A recent report suggested that gut microbes regulate 5-…