Obesity is a principal causative factor in the development of metabolic syndrome. Here we
report that increased oxidative stress in accumulated fat is an important pathogenic …

Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in
metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the …

Bile acids are essential for the solubilization and transport of dietary lipids and are the major
products of cholesterol catabolism. Results presented here show that bile acids are …

Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a hydrophilic …

1, 25-Dihydroxyvitamin D3 [1, 25 (OH) 2D3; 1, 25-dihydroxycholecalciferol or calcitriol] is
the active form of vitamin D3, a lipid-soluble vitamin that plays a role in calcium and bone …

The vitamin D receptor (VDR) mediates the effects of the calcemic hormone 1α,25-dihydroxyvitamin
D 3 [1,25(OH) 2 D 3 ]. We show that VDR also functions as a receptor for the …

Nuclear receptors are ligand-dependent transcription factors that recently have been shown
to play important roles in the metabolism of cholesterol and bile acids. Cholesterol …

Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties.
Hypoadiponectinemia seen in obesity is associated with insulin-resistant diabetes and …

… Cells were then incubated with ethanol (ETOH), 1 M 9cRA, 10 M 22(R)HC, or both ligands
and assayed for luciferase activity. Transcriptional activity was compared between wild-type …

… containing 12 mm HEPES (pH 7.9), 60 mm KCl, 4 mm Tris-HCl, 5% glycerol, 1 mm EDTA, 1
mm … containing 0.5× TBE (0.89 m Tris, 0.89m boric acid, 0.02 m disodium EDTA for 10× TBE). …