[HTML][HTML] SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova… - Nature, 2021 - nature.com
All coronaviruses known to have recently emerged as human pathogens probably originated
in bats 1 . Here we use a single experimental platform based on immunodeficient mice …

Global decomposition experiment shows soil animal impacts on decomposition are climate‐dependent

…, DL Johnson, TH Jones, M Kovarova… - Global Change …, 2008 - Wiley Online Library
… Transects ran parallel to each other and were 10 m apart. The three bags within each
transect were spaced at 0, 10, and 20 m. All blocks were at least 10 m apart, and positioned …

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

V Parravicini, M Gadina, M Kovarova, S Odom… - Nature …, 2002 - nature.com
FcεRI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the
receptor and the signaling complex organized by the linker for activation of T cells (LAT). We …

NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice

M Kovarova, PR Hesker, L Jania… - The Journal of …, 2012 - journals.aai.org
Acute inflammation in response to both exogenous and endogenous danger signals can
lead to the assembly of cytoplasmic inflammasomes that stimulate the activation of caspase-1. …

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

…, WO Thayer, RA Spagnuolo, M Kovarova… - Nature, 2020 - nature.com
Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who
receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain …

Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcɛ receptor I aggregation

M Kovářová, P Tolar, R Arudchandran… - … and cellular biology, 2001 - Taylor & Francis
… Insoluble material was removed by centrifugation, and the postnuclear supernatant was
supplemented with 6.5 μl of 0.5 M EDTA and then centrifuged at 100,000 × g for 45 min. The …

Negative regulation of immunoglobulin E–dependent allergic responses by Lyn kinase

S Odom, G Gomez, M Kovarova, Y Furumoto… - The Journal of …, 2004 - rupress.org
A role for Lyn kinase as a positive regulator of immunoglobulin (Ig)E-dependent allergy has
long been accepted. Contrary to this belief, Lyn kinase was found to have an important role …

Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency

…, L Kratz, D Cozma, M Kovářová… - Human molecular …, 2003 - academic.oup.com
… Genomic PCR was performed using Invitrogen's Platinum Taq DNA polymerase with a final
magnesium concentration of 2.0 mM. Cycling conditions were: 94C for 2 min followed by 35 …

[BOOK][B] Succession in abandoned fields: studies in Central Bohemia, Czechoslovakia

J Osbornová, M Kovárová, J Leps, K Prach - 2012 - books.google.com
Old and New Fields of Old-Field Ecology In ecology, succession occupies a place similar to
that of evolution in general biology. Ram6n Margalef, 1968. It was a great honor for me to …

[HTML][HTML] Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

SR Benhabbour, M Kovarova, C Jones… - Nature …, 2019 - nature.com
Here we report an ultra-long-acting tunable, biodegradable, and removable polymer-based
delivery system that offers sustained drug delivery for up to one year for HIV treatment or …