Prucalopride is a novel enterokinetic compound and is the first representative of the benzofuran
class. We set out to establish its pharmacological profile in various receptor binding and …

Information on the neuroanatomical expression of a given gene is critical to understanding
its function in the central nervous system. The integration of laser capture microdissection (…

Glycogen is the storage form of carbohydrate for virtually every organism from yeast to
primates. Most mammalian tissues store glucose as glycogen, with the major depots located in …

The cloning of novel G protein-coupled receptors and the search for their natural ligands, a
process called reverse pharmacology, is an excellent opportunity to discover novel …

… any of the other neurotransmitters, peptide receptors, or neurotransmitter transporters
investigated (M. Jurzak, personal communication). Specific binding was clearly detected in human …

This study documents differences in ligand binding and signal transduction properties
between the human (h) 5-hydroxytryptamine (5-HT) 4a and h5-HT 4b receptor splice variants …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome
and the leading cause of chronic liver disease in the Western world. Twenty per cent of …

… Aleksandra Moździerz, Robert Kubina and Magdalena Jurzak designed the experiments,
and critically revised the manuscript. Robert D. Wojtyczka, Rafał Stojko and Żaneta Jastrzębska…

The G protein coupling of human 5-hydroxytryptamine 5A (h5-ht 5A ) receptors was investigated
in stably transfected human embryonic kidney (HEK) 293 cells, using radioligand and …

The similar pharmacology of the 5-HT 1B and 5-HT 1D receptors, and the lack of selective
compounds sufficiently distinguishing between the two receptor subtypes, have hampered …