We report that a cysteine residue in the human β 2 -adrenergic receptor (β 2 AR) is covalently
modified by thioesterification with palmitic acid. By site-directed mutagenesis of the …

Numerous plasma membrane-bound receptors are coupled to various effectors via a family
of guanine nucleotide regulatory proteins (G proteins). Amino acid sequences of these …

… The M, and M, muscarinic acetylcholine receptors seem to be an exception to this motif as
they have relatively long third intracellular loops.-7376 As expected, the carboxyl termini of the …

Survival of myocytes and mesenchymal cells in the heart is tightly regulated by a number of
adaptive processes that are invoked with the changes that occur within the parenchyma and …

Remodeling of the extracellular matrix is beneficial during the acute wound healing stage
following tissue injury. In the short term, resident fibroblasts and myofibroblasts regulate the …

Ion transport and regulation of Na + –Ca 2+ exchange were examined for two alternatively
spliced isoforms of the canine cardiac Na + –Ca 2+ exchanger, NCX1.1, to assess the role(s) …

The Na + /Ca 2+ exchanger plays a prominent role in regulating intracellular Ca 2+ levels in
cardiac myocytes and can serve as both a Ca 2+ influx and efflux pathway. A novel inhibitor, …

In cardiac wound healing following myocardial infarction (MI), relatively inactive resident
cardiac fibroblasts phenoconvert to hypersynthetic/secretory myofibroblasts that produce large …

We constructed five genes encoding mutant human beta 2-adrenergic receptor sequence (beta
2AR) which contained 12-22 amino acid substitutions with corresponding sequence from …

Activation of guanyl nucleotide regulatory proteins (G proteins) by hormones and neurotransmitters
appears to require the formation of high affinity agonist-receptor-G protein ternary …