To define and differentiate relevant aspects of blood–brain barrier transport and distribution
in order to aid research methodology in brain drug delivery. Pharmacokinetic parameters …

… Liposomes were prepared as blank, α-M and transferrin-modified α-M, by thin-film hydration
method. Transferrin was covalently linked with α-M liposome through PEG linker and the …

Microdialysis has contributed with very important knowledge to the understanding of target-specific
concentrations and their relationship to pharmacodynamic effects from a systems …

Background Patients 80 years or older are underrepresented in scientific studies. The
objective of this study was to investigate the effectiveness of interventions performed by ward-…

Many decisions in drug development and medical practice are based on measuring blood
concentrations of endogenous and exogenous molecules. Yet most biochemical and …

Species differences occur in the brain concentrations of drugs, but the reasons for these
differences are not yet apparent. This study was designed to compare brain uptake of three …

New experimental methodologies were applied to measure the unbound brain-to-plasma
concentration ratio (K p,uu,brain ) and the unbound CSF-to-plasma concentration ratio (K p,uu,…

The aim of this study was to investigate whether blood‐brain barrier transport of morphine
was affected by the absence of mdr1a‐encoded P‐glycoprotein (Pgp), by comparing mdr1a (−/…

Concentrations of unbound drug in the interstitial fluid of the brain are not rapidly measured
in vivo. Therefore, measurement of total drug levels, ie, the amount of drug per gram of brain, …

… The transition modes for oxycodone, oxycodone-D3, and oxycodone-D6 were set to m/z
316.1 to m/z 297.9, m/z 319.1 to m/z 301, and m/z 322.2 to m/z 304, respectively. Mass …