RNA interference is a naturally occurring endogenous regulatory process where short
double-stranded RNA causes sequence-specific posttranscriptional gene silencing. Small …

Purpose. The purpose of this review is to provide an overview of the principles of and barriers
to drug transport and delivery to solid tumors. Methods. This review consists of four parts. …

Isobologram and combination index (CI) analyses are the two most popular methods for
evaluating drug interactions in combination cancer chemotherapy. As the commonly used CI-…

Background: Intravesical chemotherapy (ie, placement of the drug directly in the bladder) with
mitomycin C is beneficial for patients with superficial bladder cancer who are at high risk of …

Advances in molecular medicines have led to identification of promising targets on cellular
and molecular levels. These targets are located in extracellular and intracellular …

This study was to compare several published methodologies for evaluating the nature of
drug-drug combination, ie, curve-shift analysis, isobologram, combination index, and universal …

Based on the observation that removal of tumors from metastatic organs reversed their
chemoresistance, we hypothesized that chemoresistance is induced by extracellular factors in …

For bladder cancer, intravesical chemo/immunotherapy is widely used as adjuvant therapies
after surgical transurethal resection, while systemic therapy is typically reserved for higher …

This presentation addresses the barriers and determinants and the importance of drug-induced
apoptosis in drug transport and delivery to organs and solid tumors. In particular, we …

Cancers originating from organs in the peritoneal cavity (eg, ovarian, pancreatic, colorectal,
gastric and liver) account for approximately 250,000 new cancer cases annually in the USA. …