Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria

…, J Spatz, JP Mills, A Micoulet, M Dao, CT Lim, M Beil… - Acta biomaterialia, 2005 - Elsevier
We investigate connections between single-cell mechanical properties and subcellular
structural reorganization from biochemical factors in the context of two distinctly different human …

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia

R Windoffer, M Beil, TM Magin, RE Leube - Journal of Cell Biology, 2011 - rupress.org
Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are abundant
in epithelia and form cytoskeletal networks that contribute to cell type–specific functions, …

[HTML][HTML] Ethical considerations about artificial intelligence for prognostication in intensive care

M Beil, I Proft, D Van Heerden, S Sviri… - Intensive Care Medicine …, 2019 - Springer
Background Prognosticating the course of diseases to inform decision-making is a key
component of intensive care medicine. For several applications in medicine, new methods from …

Loss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm

…, A Van Brunt, C Wischmeyer, M Beil, M Hogan… - Nature, 2015 - nature.com
Somaclonal variation arises in plants and animals when differentiated somatic cells are
induced into a pluripotent state, but the resulting clones differ from each other and from their …

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells

M Beil, A Micoulet, G Von Wichert, S Paschke… - Nature cell …, 2003 - nature.com
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive lipid that is present in
high density lipoproteins (HDL) particles and found at increased levels in blood and …

[HTML][HTML] Detection and segmentation of cell nuclei in virtual microscopy images: a minimum-model approach

…, K Saeger, A Stenzinger, M Beil, P Hufnagl, M Dietel… - Scientific reports, 2012 - nature.com
Automated image analysis of cells and tissues has been an active research field in medical
informatics for decades but has recently attracted increased attention due to developments in …

[HTML][HTML] Ecological networks are more sensitive to plant than to animal extinction under climate change

…, E Welk, J Albrecht, M Albrecht, M Beil… - Nature …, 2016 - nature.com
Impacts of climate change on individual species are increasingly well documented, but we
lack understanding of how these effects propagate through ecological communities. Here we …

[HTML][HTML] Expression of the highly conserved RNA binding protein KOC in embryogenesis

…, B Pohl, M Wilda, U Lacher, M Beil… - Mechanisms of …, 1999 - Elsevier
The human KOC gene which is highly expressed in cancer shows typical structural features
of an RNA binding protein. We analyzed the temporal and spatial expression pattern of KOC …

The regulatory role of cell mechanics for migration of differentiating myeloid cells

…, S Schinkinger, A Bruel, M Beil… - Proceedings of the …, 2009 - National Acad Sciences
Migration of cells is important for tissue maintenance, immune response, and often altered
in disease. While biochemical aspects, including cell adhesion, have been studied in detail, …

Effect of weightlessness on cytoskeleton architecture and proliferation of human breast cancer cell line MCF‐7

J Vassy, S Portet, M Beil, G Millot… - The FASEB …, 2001 - Wiley Online Library
Because cells are sensitive to mechanical forces, weightlessness might act on stress‐dependent
cell changes. We hypothesized that the integration of environmental factors might …