Epilepsy is broadly characterized by aberrant neuronal excitability. Glutamate is the predominant
excitatory neurotransmitter in the adult mammalian brain; thus, much of past epilepsy …

… Barker-Haliski and White, unpublished data. B) The prototype ASDs, carbamazepine and …
Barker-Haliski and White, unpublished data. C) The administration of the analgesic, lidocaine, …

Early-onset Alzheimer’s disease (AD) is associated with variants in amyloid precursor protein
(APP) and presenilin (PSEN) 1 and 2. It is increasingly recognized that patients with AD …

Objective Epilepsy is a progressive neurological disease characterized by recurrent seizures
and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol ( CBD ) …

… Barker-Haliski and colleagues have shown that mice treated twice daily with anticonvulsant
… Steve White and Melissa Barker-Haliski have received funding from the National Institutes of …

It is estimated that 30%–40% of epilepsy patients are refractory to therapy and animal
models are useful for the identification of more efficacious therapeutic agents. Various well-…

It is clear that normal neuronal function relies on a tight balance between excitatory and
inhibitory neurotransmission. Inhibitory signaling through the GABAergic system can be tightly …

… Thus, m-CPP was screened for activity in the corneal kindled mouse model. Upon
administration of m-CPP 15 min prior to testing of corneal kindled mice (20 mg/kg, ip), no mice (0/8) …

Objective Epileptic spikes and seizures seem present early in the disease process of Alzheimer's
disease (AD). However, it is unclear how soluble and insoluble amyloid beta (Aβ) and …

Ganaxolone (GNX) is the 3β-methylated synthetic analog of the naturally occurring neurosteroid,
allopregnanolone (ALLO). GNX is effective in a broad range of epilepsy and behavioral …