Therapeutic implications of cancer stem cells
Most cancers comprise a heterogenous population of cells with marked differences in their
proliferative potential as well as the ability to reconstitute the tumor upon transplantation. …
proliferative potential as well as the ability to reconstitute the tumor upon transplantation. …
Potential for satellite remote sensing of ground water
MW Becker - Groundwater, 2006 - Wiley Online Library
Predicting hydrologic behavior at regional scales requires heterogeneous data that are
often prohibitively expensive to acquire on the ground. As a result, satellite‐based remote …
often prohibitively expensive to acquire on the ground. As a result, satellite‐based remote …
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
A central issue in stem cell biology is to understand the mechanisms that regulate the self-renewal
of haematopoietic stem cells (HSCs), which are required for haematopoiesis to persist …
of haematopoietic stem cells (HSCs), which are required for haematopoiesis to persist …
[PDF][PDF] BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells
…, KM O'Dwyer, JL Liesveld, PS Brookes, MW Becker… - Cell stem cell, 2013 - cell.com
Most forms of chemotherapy employ mechanisms involving induction of oxidative stress, a
strategy that can be effective due to the elevated oxidative state commonly observed in cancer …
strategy that can be effective due to the elevated oxidative state commonly observed in cancer …
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
…, CA Corbett, DC Hassane, MW Becker… - Blood, The Journal …, 2007 - ashpublications.org
Leukemia stem cells (LSCs) are thought to play a central role in the pathogenesis of acute
leukemia and likely contribute to both disease initiation and relapse. Therefore, identification …
leukemia and likely contribute to both disease initiation and relapse. Therefore, identification …
Media multitasking is associated with symptoms of depression and social anxiety
We investigated whether multitasking with media was a unique predictor of depression and
social anxiety symptoms. Participants (N=318) completed measures of their media use, …
social anxiety symptoms. Participants (N=318) completed measures of their media use, …
Tracer transport in fractured crystalline rock: Evidence of nondiffusive breakthrough tailing
MW Becker, AM Shapiro - Water Resources Research, 2000 - Wiley Online Library
… Becker, MW, Tracer tests in a fractured rock and their first passage time models, Ph.D. …
Becker, MW, and RJ Charbeneau, First passage time mathematical models for groundwater tracer …
Becker, MW, and RJ Charbeneau, First passage time mathematical models for groundwater tracer …
Leukemia stem cells in 2010: current understanding and future directions
MW Becker, CT Jordan - Blood reviews, 2011 - Elsevier
Myeloid leukemias are clonal disorders originating in a primitive multipotential hematopoietic
cell and characterized by aberrant proliferation, differentiation and maturation of leukemic …
cell and characterized by aberrant proliferation, differentiation and maturation of leukemic …
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells
R Majeti, MW Becker, Q Tian… - Proceedings of the …, 2009 - National Acad Sciences
We performed the first genome-wide expression analysis directly comparing the expression
profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem …
profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem …
Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells
…, M Goosman, S Pei, H Ye, AE Gillen, MW Becker… - Nature cancer, 2020 - nature.com
Venetoclax with azacitidine (ven/aza) has emerged as a promising treatment regimen for
acute myeloid leukemia (AML), with a high percentage of clinical remissions in newly …
acute myeloid leukemia (AML), with a high percentage of clinical remissions in newly …