This chapter describes various approaches for the preclinical assessment of druginduced
central nervous system (CNS) adverse effects. Traditionally, methods to evaluate CNS effects …

In the present article, we summarize the preclinical pharmacology of 4-{(R)-(3-aminophenyl)[4-(4-fluorobenzyl)-piperazin-1-yl]methyl}-N,N-diethylbenzamide
(AZD2327), a highly potent …

AZD2327 is a brain-penetrant agonist at δ opioid receptors which has antidepressant and
anxiolytic properties in a wide array of animal models. As part of the preclinical safety …

Hematopoietic stem cells (HSCs) give rise to all lineages of blood cells. Because HSCs must
persist for a lifetime, the balance between their proliferation and quiescence is carefully …

The current study was carried out to test the potential of a new nanomaterial (Spago Pix) as
a macromolecular magnetic MR contrast agent for tumor detection and to verify the presence …

Six months of stratospheric aerosol observations with the European Aerosol Research Lidar
Network (EARLINET) from August 2017 to January 2018 are presented. The decay phase of …

The eruption of the Icelandic volcano Eyjafjallajökull in April–May 2010 represents a "natural
experiment" to study the impact of volcanic emissions on a continental scale. For the first …

Authors evaluated the effects of selective adrenergic blockade by means of doxazosin on
blood pressure in 48 patients operated on for pheochromocytoma by a multicenter …

A first order derivative UV—spectrophotometric method for the detemiination of diltiazem
hydrochloride and mexiletine hydrochloride has been developed and validated. In the assay, …

… and Doctoral Students) UNIVIISITT This thesis, entitled The Inhibitory Effects of Opioids on
Colonic Propulsion Using the Glass Bead Test in Mice and authored by Mark R, Pietras , is …