Purpose: This study was designed to evaluate efficacy and safety of zonisamide (ZNS) as
adjunctive treatment for patients with refractory partial seizures. Methods: This randomized, …

Brain, NE, DA, and 5-HT can be assayed simultaneously from discrete samples by this
method, which is based upon the alumina method described by Anton and Sayre, utilizing acid …

To conduct a meta-analysis of the antispastic efficacy and tolerability of tizanidine, we
reviewed records of the European sponsor of tizanidine trials and selected double-blind, …

Loratadine, a new antihistamine in the non-sedating class, was evaluated for efficacy and
safety in treatment of allergic rhinitis in a multicentered study. Loratadine was found to be both …

Clinical trials with tizanidine when administered alone have shown that 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiodiazole
(tizanidine) is safe and effective for spasticity control. …

… Shellenberger MK: Effects of a-methyltyrosine on spontaneous and caudate-induced
electroencephalographic activity and regional catecholamine concentrations in the cat brain. …

GABA levels determined after the brain was removed, then frozen, were found to be generally
compatible to levels after the brain was frozen in situ provided removal and freezing were …

Rats were pretreated with α-methyl-p-tyrosine methylester, ip, 80 mg kg , every 4 hr for 12hr.
At 2, 4, 8 and 12hr of the recovery phase, spontaneous motor activity (SMA), as measured …

The mechanism by which early lead exposure alters the functional development of the brain
remains an open question. One primary avenue of approach has been to study the effects of …

SHELLENBERGER, MK AND JT ELDER: Changes in rabbit core temperature accompanying
alterations in brainstem monoamine concentrations. J. Pharmacol. Exp. Therap. 158: 219-…