XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases

…, P Larsen, E Pongo, M Handa, AH Horwitz, MK Roell… - MAbs, 2011 - Taylor & Francis
Interleukin-1β (IL-1β) is a potent mediator of inflammatory responses and plays a role in the
differentiation of a number of lymphoid cells. In several inflammatory and autoimmune …

Detailed Mechanistic Analysis of Gevokizumab, an Allosteric Anti–IL-1β Antibody with Differential Receptor-Modulating Properties

H Issafras, JA Corbin, ID Goldfine, MK Roell - Journal of Pharmacology and …, 2014 - ASPET
Interleukin-1β (IL-1β) is a proinflammatory cytokine that is implicated in many autoinflammatory
disorders, but is also important in defense against pathogens. Thus, there is a need to …

[HTML][HTML] Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1β activity

MK Roell, H Issafras, RJ Bauer, KS Michelson… - Journal of biological …, 2010 - ASBMB
Many therapeutic antibodies act as antagonists to competitively block cellular signaling
pathways. We describe here an approach for the therapeutic use of monoclonal antibodies …

Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody

DH Bedinger, ID Goldfine, JA Corbin, MK Roell… - … of Pharmacology and …, 2015 - ASPET
The monoclonal antibody XMetA is an allosteric partial agonist of the insulin receptor (IR),
which activates the metabolic Akt kinase signaling pathway while having little or no effect on …

Organization, expression and nucleotide sequence of the operon encoding R-phycoerythrin α and β subunits from the red alga Polysiphonia boldii

MK Roell, DE Morse - Plant molecular biology, 1993 - Springer
The characterization of the operon encoding the α and β subunits of rhodophytan (R)-phycoerythrin
(PE) from the macrophytic red alga Polysiphonia boldii is reported. This plastid-…

FRACTIONATION OF NUCLEAR, CHLOROPLAST, AND MITOCHONDRIAL DNA FROM POLYSIPHONIA BOLDII (RHODOPHYTA) USING A RAPID AND SIMPLE METHOD …

MK Roell, DE Morse - Journal of phycology, 1991 - Wiley Online Library
Extraction of nucleic acids from red algae is complicated by the presence of phycocolloids.
For this reason, methods used for nucleic acid isolation from other organisms are not always …

Acute treatment with XMetA activates hepatic insulin receptors and lowers blood glucose in normal mice

…, DA Kieffer, ID Goldfine, MK Roell… - Journal of Cellular …, 2015 - Wiley Online Library
… DH Bedinger, MK Roell, and SH Adams designed the experiments, DH Bedinger … ID
Goldfine, MK Roell, and SH Adams assisted with the interpretation of data and writing of …

[BOOK][B] Molecular genetics in a macrophytic red alga: Characterization of the operonencoding phycoerythrin, the major light-harvesting pigment of Polysiphonia boldii

MK Roell - 1991 - search.proquest.com
Roell and Daniel E. Morse. Cloning and nucleotide sequence of the phycoerythrin a and 0 …
Roell and Daniel E. Morse. A rapid method for isolation and fractionation of nucleic acids from …

Chloroplast gene expression: regulation at multiple levels

MK Roell, W Gruissem - Oxygenic Photosynthesis: The Light Reactions, 1996 - Springer
The plastid DNA of higher plants contains genes that primarily encode photosynthetic
proteins or products required for their synthesis. Expression of plastid genes resembles …

[CITATION][C] XOMA 052, a potent, highaffinity monoclonal antibody for the treatment of IL-1beta-mediated diseases. mAbs. 2011; 3 (1): 49–60

…, P Larsen, E Pongo, M Handa, AH Horwitz, MK Roell… - PMID