CFTR is a conductance regulator as well as a chloride channel

…, DJ Benos, ME Egan, MJ Stutts… - Physiological …, 1999 - journals.physiology.org
… It was postulated and subsequently proven by Stutts et al. (120) that CFTR dysfunction
was responsible for this basal amiloride-sensitive hyperabsorption and for defects in cAMP …

Activation of the epithelial sodium channel (ENaC) by serine proteases

BC Rossier, MJ Stutts - Annual review of physiology, 2009 - annualreviews.org
The study of human monogenic diseases [pseudohypoaldosteronism type 1 (PHA-1) and
Liddle's syndrome] as well as mouse models mimicking the salt-losing syndrome (PHA-1) or …

CFTR as a cAMP-dependent regulator of sodium channels

MJ Stutts, CM Canessa, JC Olsen, M Hamrick, JA Cohn… - Science, 1995 - science.org
Cystic fibrosis transmembrane regulator (CFTR), the gene product that is mutated in cystic
fibrosis (CF) patients, has a well-recognized function as a cyclic adenosine 3′,5′-…

Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases

…, P Kota, M Gentzsch, NV Dokholyan, MJ Stutts… - … -European Journal of …, 2010 - Springer
Mammalian airways are protected from infection by a thin film of airway surface liquid (ASL)
which covers airway epithelial surfaces and acts as a lubricant to keep mucus from adhering …

Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.

RC Boucher, MJ Stutts, MR Knowles… - The Journal of …, 1986 - Am Soc Clin Investig
The transepithelial potential difference (PD) of cystic fibrosis (CF) airway epithelium is
abnormally raised and the Cl- permeability is low. We studied the contribution of active Na+ …

Abnormal ion permeation through cystic fibrosis respiratory epithelium

MR Knowles, MJ Stutts, A Spock, N Fischer, JT Gatzy… - Science, 1983 - science.org
The epithelium of nasal tissue excised from subjects with cystic fibrosis exhibited higher
voltage and lower conductance than tissue from control subjects. Basal sodium ion absorption …

Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model

…, KN Brigman, BH Koller, RC Boucher, MJ Stutts - Science, 1994 - science.org
Stutts, unpublished data. Basal measurements were made from jejunal segments isolated
6 hours after animals were administered saline by an oro-gastric tube. Stimulated mea…

[HTML][HTML] An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton

…, SM Kreda, A Bretscher, RC Boucher, MJ Stutts… - Journal of Biological …, 1998 - ASBMB
The function of the cystic fibrosis transmembrane conductance regulator (CFTR) as a Cl −
channel in the apical membrane of epithelial cells is extensively documented. However, less is …

CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship

SE Gabriel, LL Clarke, RC Boucher, MJ Stutts - Nature, 1993 - nature.com
IN cystic fibrosis (CF), numerous epithelial cell functions are abnormal, including Cl −
conductance, sodium absorption, mucin sulphation and enzyme secretion 1–4 . Although the CF …

Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport

…, RC Boucher, MJ Stutts - American Journal of …, 2005 - journals.physiology.org
Neutrophil elastase is a serine protease that is abundant in the airways of individuals with
cystic fibrosis (CF), a genetic disease manifested by excessive airway Na + absorption and …