Objective Characterize a model of osteoarthritis (OA) induced by a surgically transecting the
medial collateral ligament and meniscus. Evaluate the effectiveness of a matrix …

Objective To determine the effect of matrix metalloproteinase (MMP) inhibitors in mono-iodoacetate-induced
arthritis in rats. Design The ability of compounds to inhibit MMPs in vitro was …

2-Aryl-3-pyrimidinyl based tumor necrosis factor-α (TNF-α) inhibitors, which contain a novel
bicyclic pyrazolone core, are described. Many showed low-nanomolar activity against …

Monoclonal antibody (MAb) technology was used to examine aggrecan metabolites and the
role of aggrecanases and matrix metalloproteinases (MMPs) in proteolysis of the …

A new generation of cyclic matrix metalloproteinase (MMP) inhibitors derived from dl-piperazinecarboxylic
acid has been described. The design involves: incorporation of hydroxamic …

Background Evaluate the potential role of p38 inhibitors for the treatment of osteoarthritis
using an animal model of joint degeneration (iodoacetate-induced arthritis) and a pain model (…

The synthesis and enzyme inhibition data for a series of thiazine- and thiazepine-based
matrix metalloproteinase (MMP) inhibitors are described. The thiazine- and thiazepine-based …

A series of hydroxamates was prepared from an aminoproline scaffold and tested for efficacy
as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for …

This communication details the synthesis, biological activity, and binding mode of a novel
class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed …

A series of P 2 -modified, orally active peptidic inhibitors of human neutrophil elastase (HNE)
are reported. These pentafluoroethyl ketone-based inhibitors were designed using …