User profiles for M. J. During
Matthew J DuringEmrys Bio Verified email at osu.edu Cited by 36674 |
Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain
MJ During, DD Spencer - The lancet, 1993 - Elsevier
… in microdialysates before and during seizures in 6 … intervals with the frequency increased
to every 3 min during a seizure. The 10 min delay enabled three 3 min baseline samples to be …
to every 3 min during a seizure. The 10 min delay enabled three 3 min baseline samples to be …
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
Adeno-associated viral (AAV) vectors are non-pathogenic, integrating DNA vectors in which
all viral genes are removed and helper virus is completely eliminated. To evaluate this …
all viral genes are removed and helper virus is completely eliminated. To evaluate this …
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial
… All patients who enrolled had surgery; during the study, no dropouts or loss of patient follow-…
routine blood and physiological indices were seen during this time. Various adverse events …
routine blood and physiological indices were seen during this time. Various adverse events …
VEGF links hippocampal activity with neurogenesis, learning and memory
… During training, we placed the rat in the lit chamber, opened the door and recorded the
latency to enter the dark chamber. After entering the dark chamber, the rat received a foot shock …
latency to enter the dark chamber. After entering the dark chamber, the rat received a foot shock …
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
MJ During, L Cao, DS Zuzga, JS Francis… - Nature medicine, 2003 - nature.com
Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is
expressed in the brain. Here we show that intracerebroventricular (icv) GLP-1 and [Ser(2)]…
expressed in the brain. Here we show that intracerebroventricular (icv) GLP-1 and [Ser(2)]…
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
…, PA Lawlor, P Leone, M Dragunow, MJ During - Nature medicine, 1999 - nature.com
… Because a more complex environment induces changes that facilitate neuronal survival
during postnatal life (that is, inhibition of the spontaneous, developmental apoptosis), the …
during postnatal life (that is, inhibition of the spontaneous, developmental apoptosis), the …
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial
Background Choroideremia is an X-linked recessive disease that leads to blindness due to
mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed …
mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed …
[PDF][PDF] Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach
… Such properties are easily observed during electrophysiological recordings, the technique
that we use throughout this paper to isolate the properties of fully functional, surface-…
that we use throughout this paper to isolate the properties of fully functional, surface-…
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial
…, L Van Meter, CV Sapan, MJ During… - The Lancet …, 2011 - thelancet.com
… During DBS surgery in patients with this disease, an infusion of the GABAergic agonist
muscimol into the subthalamic nucleus suppressed its neuronal firing rates and temporarily …
muscimol into the subthalamic nucleus suppressed its neuronal firing rates and temporarily …
Adenosine: a potential mediator of seizure arrest and postictal refractoriness
MJ During, DD Spencer - Annals of neurology, 1992 - Wiley Online Library
… that during seizures extracellular adenosine reaches levels that may depress epileptiform
activity. Samples were collected bilaterally at 3-minute intervals before, during… During seizures, …
activity. Samples were collected bilaterally at 3-minute intervals before, during… During seizures, …