User profiles for M. J. During

Matthew J During

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Verified email at osu.edu
Cited by 36674

Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain

MJ During, DD Spencer - The lancet, 1993 - Elsevier
… in microdialysates before and during seizures in 6 … intervals with the frequency increased
to every 3 min during a seizure. The 10 min delay enabled three 3 min baseline samples to be …

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

…, X Xiao, DW Pfaff, KL O'Malley, MJ During - Nature …, 1994 - nature.com
Adeno-associated viral (AAV) vectors are non-pathogenic, integrating DNA vectors in which
all viral genes are removed and helper virus is completely eliminated. To evaluate this …

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

…, D Young, K Strybing, D Eidelberg, MJ During - The Lancet, 2007 - thelancet.com
… All patients who enrolled had surgery; during the study, no dropouts or loss of patient follow-…
routine blood and physiological indices were seen during this time. Various adverse events …

VEGF links hippocampal activity with neurogenesis, learning and memory

…, DS Zuzga, Y Liu, DM Fong, D Young, MJ During - Nature …, 2004 - nature.com
During training, we placed the rat in the lit chamber, opened the door and recorded the
latency to enter the dark chamber. After entering the dark chamber, the rat received a foot shock …

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

MJ During, L Cao, DS Zuzga, JS Francis… - Nature medicine, 2003 - nature.com
Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is
expressed in the brain. Here we show that intracerebroventricular (icv) GLP-1 and [Ser(2)]…

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

…, PA Lawlor, P Leone, M Dragunow, MJ During - Nature medicine, 1999 - nature.com
… Because a more complex environment induces changes that facilitate neuronal survival
during postnatal life (that is, inhibition of the spontaneous, developmental apoptosis), the …

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

…, T Tolmachova, L Seymour, KR Clark, MJ During… - The Lancet, 2014 - thelancet.com
Background Choroideremia is an X-linked recessive disease that leads to blindness due to
mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed …

[PDF][PDF] Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach

W Lu, Y Shi, AC Jackson, K Bjorgan, MJ During… - Neuron, 2009 - cell.com
… Such properties are easily observed during electrophysiological recordings, the technique
that we use throughout this paper to isolate the properties of fully functional, surface-…

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

…, L Van Meter, CV Sapan, MJ During… - The Lancet …, 2011 - thelancet.com
During DBS surgery in patients with this disease, an infusion of the GABAergic agonist
muscimol into the subthalamic nucleus suppressed its neuronal firing rates and temporarily …

Adenosine: a potential mediator of seizure arrest and postictal refractoriness

MJ During, DD Spencer - Annals of neurology, 1992 - Wiley Online Library
… that during seizures extracellular adenosine reaches levels that may depress epileptiform
activity. Samples were collected bilaterally at 3-minute intervals before, duringDuring seizures, …