Prostaglandin H synthetase‐mediated metabolism of dopamine: implication for Parkinson's disease

MB Mattammal, R Strong, VM Lakshmi… - Journal of …, 1995 - Wiley Online Library
… " Complete system consisted of 50 p,M [2,5,6-'H]dopamine, I .0 mb/ml of either BSA or tubulin
protein or DNA, 3 units of HRP, 100 NM HO-, in a total volume of 0.5 ml. All inhibitors were …

An endogenous dopaminergic neurotoxin: implication for Parkinson's disease

MB Mattammal, JH Haring, HD Chung, G Raghu… - …, 1995 - Elsevier
Oxidation of dopamine by monoamine oxidase results in the endogenous metabolite 3,4-dihydroxyphenylacetaldehyde
(DOPAL). The toxicity of DOPAL for dopaminergic neurons was …

Renal metabolism of drugs and xenobiotics

BB Davis, MB Mattammal, TV Zenser - Nephron, 1981 - karger.com
The renal cortex, outer medulla and inner medulla exhibit different profiles of drug metabolism.
Mixed-function oxidase activity was present in cortex but not inner medulla. Cooxidation …

Inhibition of feeding by a nitric oxide synthase inhibitor: effects of aging

JE Morley, VB Kumar, MB Mattammal, S Farr… - European journal of …, 1996 - Elsevier
Nitric oxide has been demonstrated to play a role in the modulation of food intake. With
advancing age, there is a physiological decrease in food intake. The effect of the nitric oxide (NO) …

Aspirin Inhibition of N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide-induced Lesions of the Urinary Bladder Correlated with Inhibition of Metabolism by Bladder …

…, TV Zenser, G Murasaki, S Fukushima, MB Mattammal… - Cancer Research, 1981 - AACR
Mattammal. MB, and Davis, BB Co-oxidate metabolism of 2-amino-4-<5-nitro-2-furyl-thiazole …
Zenser, TV Mattammal, MB, and Davis. BB Metabolism …

Differential distribution of the mixed-function oxidase activities in rabbit kidney

TV Zenser, MB Mattammal, BB Davis - J Pharmacol Exp Ther, 1978 - hero.epa.gov
Microsomal mixed-function oxidase activities in renal cortex, outer medulla and inner
medulla were characterized and compared to liver in control and 3-methylcholanthrene-treated …

Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography—mass spectrometry

MB Mattammal, HD Chung, R Strong, FF Hsu - Journal of Chromatography …, 1993 - Elsevier
Gas chromatography—mass spectrometry was used to identify a dopamine metabolite
isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with …

Benzidine binding to nucleic acids mediated by the peroxidative activity of prostaglandin endoperoxide synthetase

TV Zenser, MB Mattammal, HJ Armbrecht, BB Davis - Cancer Research, 1980 - AACR
… A 0.5-mb aliquot of water was added to each sample. These aqueous soluble samples were
… Armbrecht,HJ, Bimbaum,LS, Zenser,TV, Mattammal,MB, and Davis, BB Renal cytochrome …

[PDF][PDF] Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase.

TV Zenser, MB Mattammal, BB Davis - Journal of Pharmacology and …, 1979 - Citeseer
Materials and Methods Materials.[‘4C (U)] benzithne(0.13 mCi/mg) was purchased from
New England Nuclear Corp., Boston, MA.[1-’4C] Arachidonic acid (56 mCi/mmol) and …

A new perspective on the inhibitory role of nitric oxide in sympathetic neurotransmission

H Macarthur, MB Mattammal, TC Westfall - Biochemical and biophysical …, 1995 - Elsevier
By using, as a model of sympathetic neurons, immortalized rat pheochromocytoma (PC12)
cells differentiated by nerve growth factor (NGF), the effect of nitric oxide on sympathetic …