REGULATION AND INHIBITION OF PHOSPHOLIPASE A2

J Balsinde, MA Balboa, PA Insel… - Annual Review of …, 1999 - annualreviews.org
▪ Abstract In recent years, there has been great interest in the study of phospholipid metabolism
in intact cell systems. Such an interest arises mainly from the discovery that cellular …

Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells

J Balsinde, MA Balboa - Cellular signalling, 2005 - Elsevier
Mammalian cells contain several calcium-independent phospholipase A 2 (PLA 2 ) enzymes.
The best studied of them is the so-called Group VIA PLA 2 (iPLA 2 -VIA), which is an 85-88 …

Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases

…, AM Astudillo, D Balgoma, MA Balboa… - … et Biophysica Acta (BBA …, 2009 - Elsevier
Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids,
are key mediators of a wide variety of physiological and pathophysiological states. AA, …

Dynamics of arachidonic acid mobilization by inflammatory cells

AM Astudillo, D Balgoma, MA Balboa… - Biochimica et Biophysica …, 2012 - Elsevier
The development of mass spectrometry-based techniques is opening new insights into the
understanding of arachidonic acid (AA) metabolism. AA incorporation, remodeling and …

Oxidative stress and arachidonic acid mobilization

MA Balboa, J Balsinde - Biochimica et Biophysica Acta (BBA)-Molecular …, 2006 - Elsevier
Reactive oxygen species are known to contribute to tissue damage during injury and
inflammation. However, these species can also be sensed by the cells and trigger intracellular …

[HTML][HTML] Antisense inhibition of group VI Ca2+-independent phospholipase A2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages

J Balsinde, MA Balboa, EA Dennis - Journal of biological chemistry, 1997 - ASBMB
A major issue in lipid signaling relates to the role of particular phospholipase A 2 isoforms in
mediating receptor-triggered responses. This has been difficult to study because of the lack …

[HTML][HTML] Involvement of Calcium-independent Phospholipase A2in Hydrogen Peroxide-induced Accumulation of Free Fatty Acids in Human U937 Cells

MA Balboa, J Balsinde - Journal of Biological Chemistry, 2002 - ASBMB
Previous studies have demonstrated that U937 cells are able to mobilize arachidonic acid (AA)
and synthesize prostaglandins in response to receptor-directed and soluble stimuli by a …

Phosphatidylinositol 4,5-Bisphosphate Anchors Cytosolic Group IVA Phospholipase A2 to Perinuclear Membranes and Decreases Its Calcium Requirement for …

…, MS Crespo, J Balsinde, MA Balboa - Molecular biology of …, 2006 - Am Soc Cell Biol
The eicosanoids are centrally involved in the onset and resolution of inflammatory processes.
A key enzyme in eicosanoid biosynthesis during inflammation is group IVA phospholipase …

[HTML][HTML] Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human …

…, JM Rubio, L Gil-de-Gómez, MA Balboa… - Journal of Lipid …, 2012 - ASBMB
… Antibodies against p-cPLA 2 (Ser505), p-p38(Thr180/Tyr182) and p-JNK(Thr183/Tyr185)
were purchased from Cell Signaling (Danvers, MA). The cPLA 2 α inhibitor pyrrophenone was …

Coordinate regulation of TLR-mediated arachidonic acid mobilization in macrophages by group IVA and group V phospholipase A2s

V Ruipérez, AM Astudillo, MA Balboa… - The Journal of …, 2009 - journals.aai.org
Macrophages can be activated through TLRs for a variety of innate immune responses. In
contrast with the wealth of data existing on TLR-dependent gene expression and resultant …