Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice

…, A Grodet, A Mansouri, R Nguyen, M Tinel… - Gastroenterology, 2002 - Elsevier
Background & Aims: A single dose of alcohol causes transient hepatic mitochondrial DNA (mtDNA)
depletion in mice followed by increased mtDNA synthesis and an overshoot of …

A role for transforming growth factor α as an inducer of astrogliosis

…, JM Weinitz, M Coulpier, C Fages, M Tinel… - Journal of …, 1998 - Soc Neuroscience
TGFα is a member of the epidermal growth factor (EGF) family with which it shares the same
receptor, the EGF receptor (EGFR). Synthesis of TGFα and EGFR in reactive astrocytes …

Inactivation of cytochrome P-450 by the drug methoxsalen.

H Fouin-Fortunet, M Tinel, V Descatoire… - … of Pharmacology and …, 1986 - ASPET
Administration of methoxsalen (50 mumol X kg-1 ip) increased 4-fold the hexobarbital sleeping
time in rats; at this low dose, SKF 525-A, piperonyl butoxide and cimetidine had little or …

Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy

J Elkahwaji, MA Robin, A Berson, M Tinel… - Biochemical …, 1999 - Elsevier
… · 10 6 IL-2 units/m 2 , compared to 7 patients who did not receive IL-2. In contrast, in 6 patients
receiving daily doses of 9 or 12 · 10 6 IL-2 units/m 2 , the mean values for immunoreactive …

Inactivation of human liver cytochrome P-450 by the drug methoxsalen and other psoralen derivatives

M Tinel, J Belghiti, V Descatoire, G Amouyal… - Biochemical …, 1987 - Elsevier
… Monooxygenase activities were also decreased in the presence of 12.5 m bergapten (5-methoxypsoralen)
or 12.5 PM psoralen, but not with 12.5 m trioxsalen (trimethylpsoralen). CO-…

Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies.

M Bourdi, M Tinel, PH Beaune, D Pessayre - Molecular Pharmacology, 1994 - ASPET
The antihypertensive drug dihydralazine may, on rare occasions, cause immunoallergic
hepatitis characterized by anti-cytochrome P450 (P450)1A2 autoantibodies. To understand the …

The anti-inflammatory drug, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), uncouples mitochondria and induces mitochondrial permeability transition in human …

A Berson, S Cazanave, V Descatoire, M Tinel… - … of Pharmacology and …, 2006 - ASPET
… Mice were killed by cervical dislocation, and the liver was removed, weighed, minced, and
homogenized in 3 volumes of ice-cold 0.154 M KCl and 0.01 M sodium potassium phosphate …

Extreme precipitation time trends in Ontario, 1960–2010

…, A Sarhadi, M Tinel, M Suthar - Hydrological …, 2016 - Wiley Online Library
The impact of climate change on the behaviour of intensity–duration–frequency curves is
critical to the estimation of design storms, and thus to the safe design of drainage infrastructure. …

[PDF][PDF] Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides.

M Tinel, V Descatoire, D Larrey, J Loeper… - … of Pharmacology and …, 1989 - Citeseer
Repeated administration of clanthromycin(0.5 mmol. kg1 po daily for 5 days) to rats
increased markedly the same cytochrome P-450 isoenzyme(P-450p) as that induced by …

Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats.

P Letteron, V Descatoire, D Larrey, M Tinel… - … of Pharmacology and …, 1986 - ASPET
8-Methoxypsoralen has been shown to both inactivate and induce microsomal enzymes.
We report here the effects of other psoralen derivatives in rats. CO-binding cytochrome P-450 …