[HTML][HTML] Quantitative assessment of tear production: A review of methods and utility in dry eye drug discovery
M Senchyna, MB Wax - Journal of ocular biology, diseases, and …, 2008 - Springer
The successful development of a therapeutic agent targeting treatment of dry eye syndrome
necessitates the demonstration of drug efficacy for both sign and symptom endpoints. As …
necessitates the demonstration of drug efficacy for both sign and symptom endpoints. As …
Lysozyme and lipid deposition on silicone hydrogel contact lens materials
L Jones, M Senchyna, MA Glasier, J Schickler… - Eye & contact …, 2003 - journals.lww.com
Purpose. We sought to determine whether there were differences in lysozyme (quantity and
conformation) and lipid deposition on in vivo worn conventional (etafilcon) and silicone …
conformation) and lipid deposition on in vivo worn conventional (etafilcon) and silicone …
Kinetics of In Vitro Lysozyme Deposition on Silicone Hydrogel, PMMA, and FDA Groups I, II, and IV Contact Lens Materials
LN Subbaraman, MA Glasier, M Senchyna… - Current eye …, 2006 - Taylor & Francis
We sought to compare the kinetics of in vitro lysozyme deposition on silicone hydrogel (SH),
polymethyl methacrylate (PMMA), and FDA groups I, II, and IV contact lenses. Lenses were …
polymethyl methacrylate (PMMA), and FDA groups I, II, and IV contact lenses. Lenses were …
Impact of time between collection and collection method on human tear fluid osmolarity
A Keech, M Senchyna, L Jones - Current eye research, 2013 - Taylor & Francis
Aim: To generate data on the variability of tear osmolarity in a control (normal, non-dry eye)
and symptomatic dry eye population (Ocular Surface Disease Index: OSDI ≥20). A …
and symptomatic dry eye population (Ocular Surface Disease Index: OSDI ≥20). A …
Quantitative and conformational characterization of lysozyme deposited on balafilcon and etafilcon contact lens materials
M Senchyna, L Jones, D Louie, C May… - Current eye …, 2004 - Taylor & Francis
Purpose. To determine whether differences in lysozyme deposition and/or activity exist on
worn etafilcon and balafilcon contact lenses following care with a polyquaternium-based …
worn etafilcon and balafilcon contact lenses following care with a polyquaternium-based …
The dilution of benzalkonium chloride (BAK) in the tear film
…, B Amoozgar, H Sheardown, M Senchyna - Advances in …, 2006 - Springer
The claim that benzalkonium chloride (BAK) synergistically enhances the antibiotic efficacy
of gatifloxacin ophthalmic solution 0.3% (preserved with 0.005% BAK [50 μg/mL), Zymar; …
of gatifloxacin ophthalmic solution 0.3% (preserved with 0.005% BAK [50 μg/mL), Zymar; …
Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye
IK Gipson, SJ Spurr-Michaud, M Senchyna, R Ritter III… - Cornea, 2011 - journals.lww.com
Purpose: To determine if levels of the glycocalyx membrane mucins, MUC1 and MUC16,
and the secreted goblet cell mucin MUC5AC are altered in conjunctival cells and tears of …
and the secreted goblet cell mucin MUC5AC are altered in conjunctival cells and tears of …
[PDF][PDF] Temperature-induced transitions in the structure and interfacial rheology of human meibum
…, CI Leiske, DR Leiske, MF Toney, M Senchyna… - Biophysical journal, 2012 - cell.com
… The same meibum film at 35 C is shown at the same levels of compression, although the
resultant surface pressures were 2 mN/m (c) and 15 mN/m (d). The mean molecular area of …
resultant surface pressures were 2 mN/m (c) and 15 mN/m (d). The mean molecular area of …
[HTML][HTML] Biophysical and morphological evaluation of human normal and dry eye meibum using hot stage polarized light microscopy
…, A McMahon, H Ketelson, M Senchyna… - … & visual science, 2014 - jov.arvojournals.org
… It was also noticed that BSA was capable of increasing the T m of the WE around the
protein particles by a few degrees Celsius as the lipid birefringence in the presence of BSA …
protein particles by a few degrees Celsius as the lipid birefringence in the presence of BSA …
[HTML][HTML] MUC1 expression in Sjogren's syndrome, KCS, and control subjects
…, E Joyce, L Jones, R Ritter III, M Senchyna - Molecular …, 2010 - ncbi.nlm.nih.gov
Purpose To quantify and compare human mucin 1 (MUC1) protein and mRNA expression in
tears and conjunctival epithelial cells collected from Sjogren’s syndrome (SS), non-Sjogren’…
tears and conjunctival epithelial cells collected from Sjogren’s syndrome (SS), non-Sjogren’…