Obesity and hypertension

N Mikhail, MS Golub, ML Tuck - Progress in cardiovascular diseases, 1999 - Elsevier
Substantial evidence from epidemiological data supports a link between obesity and
hypertension. However, the relationship between the two disorders is not straightforward and most …

Obesity, the sympathetic nervous system, and essential hypertension.

ML Tuck - Hypertension, 1992 - Am Heart Assoc
There is ample evidence that the sympathetic nervous system is important in the etiology of
essential hypertension. Plasma catecholamines such as norepinephrine and epinephrine …

Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin–angiotensin system

…, K Yamamoto, MD Nyby, H Makino, ML Tuck - Journal of …, 2008 - journals.lww.com
… Cells were then solubilized with 0.5 ml of 1N NaOH, then neutralized with 0.5 ml 1N HCl.
The radioactivity of each sample was determined using liquid scintillation counting. …

The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients

ML Tuck, J Sowers, L Dornfeld, G Kledzik… - New England Journal …, 1981 - Mass Medical Soc
We investigated the relation between changes in the renin-aldosterone axis and reduction in
blood pressure in 25 obese patients placed on a 12-week reducing diet; sodium intake was …

The effect of aldosterone on glucose metabolism

DB Corry, ML Tuck - Current hypertension reports, 2003 - Springer
There is an association of glucose intolerance and diabetes with primary aldosteronism, but
the frequency and mechanisms are not clear. This paper reviews the possible mechanisms …

Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation

…, H Kawaguchi, H Mikami, T Ogihara, ML Tuck - …, 2003 - Am Heart Assoc
It has been reported that hypertension and obesity often coexist with hyperuricemia. To clarify
the relations between serum uric acid, plasma norepinephrine, and insulin or leptin levels …

Sympathetic nerve hyperactivity precedes hyperinsulinemia and blood pressure elevation in a young, nonobese Japanese population

…, H Mikami, T Ogihara, ML Tuck - American journal of …, 1997 - academic.oup.com
… 3.6%; sensitivity = 0.010 to 20 ng/mL), and plasma immunoreactive insulin was measured by
… 2.2%; sensitivity = 0.75 to 300 μU/mL). Blood glucose and lipid fractions were measured by …

Weight gain–induced blood pressure elevation

K Masuo, H Mikami, T Ogihara, ML Tuck - Hypertension, 2000 - Am Heart Assoc
This study was conducted to evaluate the mechanisms in weight gain–induced blood pressure
(BP) elevation focusing, in particular, on the contributions of sympathetic nervous system …

β2- and β3-Adrenergic Receptor Polymorphisms Are Related to the Onset of Weight Gain and Blood Pressure Elevation Over 5 Years

…, T Katsuya, Y Fu, H Rakugi, T Ogihara, ML Tuck - Circulation, 2005 - Am Heart Assoc
Background— The genes responsible for obesity are candidate genes for obesity-related
diseases, such as hypertension. Functional polymorphisms in the β 2 - and β 3 -adrenergic …

Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD …

…, T Morihara, D Dhoot, MD Nyby, ML Tuck… - Journal of …, 2007 - Soc Neuroscience
Environmental and genetic factors, notably ApoE4, contribute to the etiology of late-onset
Alzheimer's disease (LOAD). Reduced mRNA and protein for an apolipoprotein E (ApoE) …