Pharmacological properties of 2-[4-(2-thiazolyloxy)-phenyl]-propionic acid (480156-S), a new non-steroidal antiinflammatory agent.
K Hirose, H Jyoyama, Y Kojima, M Eigyo… - Arzneimittel …, 1984 - europepmc.org
In terms of antiinflammatory activity in acute and chronic animal models, 2-[4-(2-thiazolyloxy)-phenyl]-propionic
acid (480156-S) was more active than ibuprofen but inferior to …
acid (480156-S) was more active than ibuprofen but inferior to …
Central effect of atrial natriuretic polypeptide on angiotensin II-stimulated vasopressin secretion in concious rats
…, Y Saito, H Ohno, A Kanai, G Katsuura, M Eigyo… - European journal of …, 1986 - Elsevier
… The standard buffer for the RIA was 0.1 M phosphate buffer, pH 7.0, containing 0.3% gelatin
(Merk, Darmstadt, West Germany), 1 mM Na2EDTA, 0.2 mM cystine, 0.1% Triton X-100 and …
(Merk, Darmstadt, West Germany), 1 mM Na2EDTA, 0.2 mM cystine, 0.1% Triton X-100 and …
Central action of atrial natriuretic polypeptide on blood pressure in conscious rats
…, Y Saito, G Katsuura, T Shiomu, M Eigyo… - Brain research …, 1986 - Elsevier
… The suppressive effect of centrally admmistered ANP on the AII-induced pressor response
shown m this study suggests the participation of brain ANP, in combination with brain RAS, …
shown m this study suggests the participation of brain ANP, in combination with brain RAS, …
Ischemia-induced irreversible deficit of memory function in gerbils
A Katoh, C Ishibashi, T Shiomi, Y Takahara, M Eigyo - Brain research, 1992 - Elsevier
Ischemia for 5 min temporarily increased locomotor activity in gerbils after 1 and 3 days.
Temporary increases were also noted within 7 and 5 days after 20-min ischemia and repeated …
Temporary increases were also noted within 7 and 5 days after 20-min ischemia and repeated …
Synthesis and Structure− Activity Relationships of Fused Imidazopyridines: A New Series of Benzodiazepine Receptor Ligands
…, N Chomei, M Adachi, T Fujishita, M Eigyo… - Journal of medicinal …, 1996 - ACS Publications
2-Arylimidazo[4,5-c]quinolines and analogous fused imidazopyridines were synthesized and
evaluated as benzodiazepine receptor ligands. Affinity to the receptors was greatly affected …
evaluated as benzodiazepine receptor ligands. Affinity to the receptors was greatly affected …
Thienylpyrazoloquinolines with high affinity to benzodiazepine receptors: Continuous shift from inverse agonist to agonist properties depending on the size of the alkyl …
H Shindo, S Takada, S Murata, M Eigyo… - Journal of medicinal …, 1989 - ACS Publications
2-(5-Alkylthien-3-yl)-(1), 2-(4-alkylthien-2-yl)-(2), and 2-(5-alkylthien-2-yl)-2, 5-dihydro-37f-pyrazolo
[4, 3-c] quinolines (3) were prepared in four steps starting from ethyl 4-…
[4, 3-c] quinolines (3) were prepared in four steps starting from ethyl 4-…
Behavioral and electroencephalographic properties of duloxetine (LY248686), a reuptake inhibitor of norepinephrine and serotonin, in mice and rats.
…, M Eigyo, C Ishibashi, Y Naitoh, M Takeuchi… - … of Pharmacology and …, 1995 - ASPET
Duloxetine is a dual inhibitor of norepinephrine and serotonin reuptake. Duloxetine (3.13-50
mg/kg po) significantly prevented tetrabenazine (1 and 50 mg/kg sc)-induced ptosis in mice …
mg/kg po) significantly prevented tetrabenazine (1 and 50 mg/kg sc)-induced ptosis in mice …
Possible involvement of central atrial natriuretic polypeptide in regulation of hypothalamo-pituitary-adrenal axis in conscious rats
…, M Sakamoto, A Sugawara, Y Saito, M Eigyo… - Neuroscience …, 1986 - Elsevier
The effects of intracerebroventricular (icv) administration of angiotensin II (AII) and atrial
natriuretic polypeptide (ANP) on the plasma corticosterone level were studied in conscious, …
natriuretic polypeptide (ANP) on the plasma corticosterone level were studied in conscious, …
A novel benzodiazepine inverse agonist, S-8510, as a cognitive enhancer.
K Kawasaki, M Eigyo, M Ikeda, T Kihara… - Progress in neuro …, 1996 - europepmc.org
1. Pharmacological actions of a novel benzodiazepine receptor ligand, S-8510 (2-(3-isoxazolyl)-3,
6, 7, 9-tetrahydroimidazo [4, 5-d] pyrano+++[4, 3-b] pyridine monophosphate …
6, 7, 9-tetrahydroimidazo [4, 5-d] pyrano+++[4, 3-b] pyridine monophosphate …
Protective effect of CCK-8 and ceruletide on glutamate-induced neuronal cell death in rat neuron cultures: possible involvement of CCK-B receptors
G Katsuura, S Shinohara, H Shintaku, M Eigyo… - Neuroscience …, 1991 - Elsevier
… 10 -9 and 10 -6 M significantly inhibited the increase in the … of gastrin-I, at 10 -6 M produced
little inhibition of the glutamate-… 10-7 M for CCK-8, 10 -8 M for CLT, and 10 -6 M for gastrin-I. …
little inhibition of the glutamate-… 10-7 M for CCK-8, 10 -8 M for CLT, and 10 -6 M for gastrin-I. …