Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of
important bioactive lipids, including the apoptotic compound ceramide and the proliferative …

A critical step in the mechanism of action of inflammatory cytokines is the stimulation of
sphingolipid metabolism, including activation of sphingosine kinase (SK), which produces the …

Purpose: Sphingosine kinases (SK1 and SK2) regulate tumor growth by generating the
mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). This phase I study …

Aim Activation of sphingosine kinase (SK) is a key response to many inflammatory processes.
The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, …

Expression of the drug transport proteins, including P-glycoprotein (Pgp), in the brain vascular
endothelium represents a challenge for the effective delivery of drugs for the treatment of …

purpose. The increased vascular permeability and pathogenic angiogenesis observed in
diabetic retinopathy are induced, at least in part, by local inflammation and vascular …

Pro-inflammatory cytokines like TNF-α activate sphingosine kinase (SK). Therefore, inhibition
of SK is a potential molecular target for the treatment of rheumatoid arthritis. Aims The …

The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive
humanitarian and economic stress across the world. Although antivirals active against mild …

Background/Aims: Osteoarthritis (OA) is a progressive degenerative disease characterized
by cartilage degradation and chondrocyte apoptosis, which may involve aberrant …

Exposure to ionizing radiation (IR) is a lingering threat from accidental or terroristic nuclear
events, but is also widely used in cancer therapy. In both cases, host inflammatory responses …