The good and the bad of glutamate receptor RNA editing
A Filippini, D Bonini, L La Via, A Barbon - Molecular Neurobiology, 2017 - Springer
Glutamate receptors play a key role in excitatory synaptic transmission and plasticity in the
central nervous system (CNS). Their channel properties are largely dictated by the subunit …
central nervous system (CNS). Their channel properties are largely dictated by the subunit …
[HTML][HTML] Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats …
P Tornese, N Sala, D Bonini, T Bonifacino, L La Via… - Neurobiology of …, 2019 - Elsevier
Depression is a debilitating mental disease, characterized by persistent low mood and
anhedonia. Stress represents a major environmental risk factor for depression; the complex …
anhedonia. Stress represents a major environmental risk factor for depression; the complex …
Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels
…, C Orlandi, L Musazzi, A Mallei, L La Via… - Neurochemistry …, 2011 - Elsevier
Growing evidence suggests a pivotal role for glutamatergic neurotransmission in the
pathophysiology of major depressive disorder and in the action of antidepressants. The main aim of …
pathophysiology of major depressive disorder and in the action of antidepressants. The main aim of …
Regulation of editing and expression of glutamate α-amino-propionic-acid (AMPA)/kainate receptors by antidepressant drugs
BACKGROUND: Several reports have shown that the glutamatergic system is involved in
both the pathogenesis of affective and stress-related disorders and in the action of …
both the pathogenesis of affective and stress-related disorders and in the action of …
Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse
The fragile X syndrome (FXS), the most common form of inherited intellectual disability, is
due to the absence of FMRP, a protein regulating RNA metabolism. Recently, an unexpected …
due to the absence of FMRP, a protein regulating RNA metabolism. Recently, an unexpected …
[HTML][HTML] miR-9-5p is involved in the rescue of stress-dependent dendritic shortening of hippocampal pyramidal neurons induced by acute antidepressant treatment …
J Mingardi, L La Via, P Tornese, G Carini, K Trontti… - Neurobiology of …, 2021 - Elsevier
Converging clinical and preclinical evidence demonstrates that depressive phenotypes are
associated with synaptic dysfunction and dendritic simplification in cortico-limbic …
associated with synaptic dysfunction and dendritic simplification in cortico-limbic …
Modulation by chronic stress and ketamine of ionotropic AMPA/NMDA and metabotropic glutamate receptors in the rat hippocampus
…, N Sala, F Bono, C Fiorentini, L La Via… - Progress in Neuro …, 2021 - Elsevier
Converging clinical and preclinical evidence has shown that dysfunction of the glutamate
system is a core feature of major depressive disorder. In this context, the N-methyl-d-aspartate (…
system is a core feature of major depressive disorder. In this context, the N-methyl-d-aspartate (…
[HTML][HTML] Acute ketamine facilitates fear memory extinction in a rat model of PTSD along with restoring glutamatergic alterations and dendritic atrophy in the prefrontal …
…, J Mingardi, E Schiavon, L La Via… - Frontiers in …, 2022 - frontiersin.org
Stress represents a major risk factor for psychiatric disorders, including post-traumatic stress
disorder (PTSD). Recently, we dissected the destabilizing effects of acute stress on the …
disorder (PTSD). Recently, we dissected the destabilizing effects of acute stress on the …
[HTML][HTML] AMPA receptor regulation at the mRNA and protein level in rat primary cortical cultures
C Orlandi, L La Via, D Bonini, C Mora, I Russo… - PloS one, 2011 - journals.plos.org
Ionotropic glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors
are the major mediators of fast synaptic neurotransmission. In this work, we used primary …
are the major mediators of fast synaptic neurotransmission. In this work, we used primary …
AMPA receptor properties are modulated in the early stages following pilocarpine-induced status epilepticus
I Russo, D Bonini, LL Via, S Barlati, A Barbon - Neuromolecular medicine, 2013 - Springer
Glutamate over-activation and the consequent neuronal excitotoxicity have been identified
as crucial players in brain dysfunctions such as status epilepticus (SE). Owing to the central …
as crucial players in brain dysfunctions such as status epilepticus (SE). Owing to the central …