Endothelins were discovered more than thirty years ago as potent vasoactive compounds.
Beyond their well-documented cardiovascular properties, however, the contributions of the …

The serine protease chymase has been reported to generate intracardiac angiotensin-II (Ang-II)
from Ang-I as well as an intermediate precursor of endothelin-1 (ET-1), ET-1 (1–31) from …

Important structural differences imply that human and mouse mast cell chymases may differ
with respect to their enzymatic properties. We compared in this study the catalytic efficiencies …

Chymase, a mast cell serine protease involved in the generation of multiple cardiovascular
factors, such as angiotensin II and endothelin-1 (ET-1), is elevated and participates in tissue …

Experimental autoimmune encephalomyelitis (EAE) is a mouse model that reproduces
cardinal signs of clinical, histopathological, and immunological features found in Multiple …

Aims To determine the impact of mixed endothelin receptor antagonist and mouse mast cell
protease-4 (mMCP-4) in the development of atherosclerosis in the mouse model. Materials …

In the past three decades, endothelin and endothelin receptor antagonists have received
great scientific and clinical interest, leading to the publication of more than 27,000 scientific …

Multiple sclerosis is a neurodegenerative disease affecting predominantly female patients
between 20 and 45 years of age. We previously reported the significant contribution of mouse …

The serine protease chymase converts intravenously (iv)- administered big-endothelin-1 to
endothelin-1 (ET-1) in the mouse in vivo. The mouse mast cell protease 4 (mMCP-4) is …

The role of mouse mast cell protease 4 (mMCP-4) in the in vivo conversion of Big-ET-1 to ET-1,
via the hydrolysis of the inactive intermediate, ET-1 (1-31), has been recently reported (…