The data on adverse drug reactions (ADRs) are incomplete, unrepresentative, uncontrolled,
and lacking in operational criteria for identifying ADRs. No quantitative conclusions can be …

The placebo effect has been the subject of much controversy. For a scientific investigation of
placebo effects to advance it is important to establish whether a placebo response in any …

Sixty-six subjects, 64 of whom were female hospital or medical school employees, were asked
if they were willing to take two tablets of "acetylhydroxybenzoate" or a placebo when they …

1.1. A group of 162 postoperative patients was observed for the ability of such patients to
receive significant relief of pain from subcutaneous injections of placebo and of morphine. 2.2. …

Suggestions are made for the conduct of chemotherapy trials in patients with cancer.
Application of the principles involved are illustrated in a comparative study of triethylene …

The research and development costs of 93 randomly selected new chemical entities (NCEs)
were obtained from a survey of 12 US-owned pharmaceutical firms. These data were used …

The literature on analgesic testing in man reveals a series of informational gaps. These
include a failure to document the occurrence of “trials that failed,” the problems associated with …

We compared the sensitivity of different types of visual analog scales and of descriptive pain
terms in healthy volunteers and in postoperative patients. One hundred and seven …

The evaluation of adverse drug reactions in clinical practice is somewhat arbitrary and is
characterized by considerable differences of opinion. This report presents a decision table …

T he doctor of today is under constant bombardment with claims as to the efficacy of drugs,
old and new. It is difficult, if not impossible, to read a journal, attend a medical meeting, or …