Plasma butyrylcholinesterase regulates ghrelin to control aggression
VP Chen, Y Gao, L Geng, RJ Parks… - Proceedings of the …, 2015 - National Acad Sciences
Ongoing mouse studies of a proposed therapy for cocaine abuse based on viral gene transfer
of butyrylcholinesterase (BChE) mutated for accelerated cocaine hydrolysis have yielded …
of butyrylcholinesterase (BChE) mutated for accelerated cocaine hydrolysis have yielded …
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
L Geng, CJ Huntoon, LM Karnitz - Journal of cell biology, 2010 - rupress.org
The Fanconi anemia (FA) network is important for the repair of interstrand DNA cross-links.
A key event in FA pathway activation is the monoubiquitylation of the FA complementation …
A key event in FA pathway activation is the monoubiquitylation of the FA complementation …
Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis
S Brimijoin, VP Chen, YP Pang, L Geng… - Chemico-biological …, 2016 - Elsevier
Butyrylcholinesterase (BChE) has long been regarded as an “orphan enzyme” with no specific
physiological role other than to metabolize exogenous bioactive esters in the diet or in …
physiological role other than to metabolize exogenous bioactive esters in the diet or in …
Butyrylcholinesterase deficiency promotes adipose tissue growth and hepatic lipid accumulation in male mice on high-fat diet
Despite numerous reports of relationships between weight gain and butyrylcholinesterase (BChE),
this enzyme's role in the genesis of obesity remains unclear, but recent research …
this enzyme's role in the genesis of obesity remains unclear, but recent research …
Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway
CJ Huntoon, MD Nye, L Geng, KL Peterson, KS Flatten… - Cancer research, 2010 - AACR
Heat shock protein 90 (HSP90), which regulates the functions of multiple oncogenic signaling
pathways, has emerged as a novel anticancer therapeutic target, and multiple small-…
pathways, has emerged as a novel anticancer therapeutic target, and multiple small-…
[HTML][HTML] Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis
VP Chen, Y Gao, L Geng, S Brimijoin - International journal of obesity, 2017 - nature.com
Background: Ghrelin is the only orexigenic hormone known to stimulate food intake and
promote obesity and insulin resistance. We recently showed that plasma ghrelin is controlled by …
promote obesity and insulin resistance. We recently showed that plasma ghrelin is controlled by …
Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B
L Geng, X Zhang, S Zheng… - Molecular and cellular …, 2007 - Am Soc Microbiol
Artemis is a phospho-protein that has been shown to have roles in V (D) J recombination,
nonhomologous end-joining of double-strand breaks, and regulation of the DNA damage-…
nonhomologous end-joining of double-strand breaks, and regulation of the DNA damage-…
Poly (ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells
AM Huehls, JM Wagner, CJ Huntoon, L Geng… - Cancer research, 2011 - AACR
5-Fluorouracil (5-FU) and 5-fluorodeoxyuridine (FdUrd, floxuridine) have activity in multiple
tumors, and both agents undergo intracellular processing to active metabolites that disrupt …
tumors, and both agents undergo intracellular processing to active metabolites that disrupt …
[HTML][HTML] Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil
L Geng, AM Huehls, JM Wagner, CJ Huntoon… - PloS one, 2011 - journals.plos.org
The fluoropyrimidines 5-fluorouracil (5-FU) and FdUrd (5-fluorodeoxyuridine; floxuridine) are
the backbone of chemotherapy regimens for colon cancer and other tumors. Despite their …
the backbone of chemotherapy regimens for colon cancer and other tumors. Despite their …
Butyrylcholinesterase gene transfer in obese mice prevents postdieting body weight rebound by suppressing ghrelin signaling
VP Chen, Y Gao, L Geng… - Proceedings of the …, 2017 - National Acad Sciences
The worldwide prevalence of obesity is increasing at an alarming rate but treatment options
remain limited. Despite initial success, weight loss by calorie restriction (CR) often fails …
remain limited. Despite initial success, weight loss by calorie restriction (CR) often fails …