With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical
need to identify, target and manipulate specific cell populations expressing the mu-opioid …

Anhedonia, the loss of pleasure from previously rewarding activities, is implicated in several
neuropsychiatric conditions, including major depressive disorder (MDD). In order to …

The pervasive use of opioid compounds for pain relief is rooted in their utility as one of the
most effective therapeutic strategies for providing analgesia. While the detrimental side effects …

Background Anhedonia, the loss of pleasure in previously rewarding activities, is a
prominent feature of major depressive disorder and often resistant to first-line antidepressant …

Attenuating emesis elicited by both disease and medical treatments of disease remains a
critical public health challenge. Although cannabinergic medications have been used in …

The basolateral amygdala (BLA) is essential for assigning positive or negative valence to
sensory stimuli. Noxious stimuli that cause pain are encoded by an ensemble of nociceptive …

Background Emesis has significant evolutionary value as a defense mechanism against
ingested toxins; however, it is also one of the most common adverse symptoms associated with …

Anhedonia, the loss of pleasure derived from previously rewarding activities, is a behavioral
phenotype that is implicated in several neuropsychiatric conditions, including major …

… The author(s) declared the following potential conflicts of interest with respect to the
research, authorship, and/or publication of this article: Author Missi Wooldridge has previously …

Agent-based models (ABMs) are a promising tool to simulate complex environments. Their
rapid adoption requires scalable specification, efficient data-driven calibration, and validation …