Importance Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO)
have been recommended for acute hypoxemic respiratory failure in patients with COVID-19…

Plastic waste can promote microbial colonization by pathogens implicated in outbreaks of
disease in the ocean. We assessed the influence of plastic waste on disease risk in 124,000 …

Epstein–Barr virus-induced gene 2 (EBI2, also known as GPR183) is a G-protein-coupled
receptor that is required for humoral immune responses; polymorphisms in the receptor have …

B cell follicles are specialized microenvironments that support events necessary for humoral
immunity 1 , 2 , 3 . After antigen encounter, activated B cells initially seek T-cell help at the …

Background Chronic limb-threatening ischaemia is the severest manifestation of peripheral
arterial disease and presents with ischaemic pain at rest or tissue loss (ulceration, gangrene, …

The prominent display of opsonized antigen by follicular dendritic cells (FDCs) has long
favored the view that they serve as antigen-presenting cells for B cells. Surprisingly, however, …

Humoral immune responses depend on B cells encountering antigen, interacting with helper
T cells, proliferating and differentiating into low-affinity plasma cells or, after organizing into …

Background: Prospective population-based studies are important to accurately determine the
incidence and characteristics of stroke associated with atrial fibrillation (AF), while avoiding …

Childhood overweight is at an all-time high in the United States. In an effort to better understand
children's, parents', and teachers' attitudes, perceptions, and behaviors about preventing …

7α,25-dihydroxycholesterol (7α,25-OHC) is a ligand for the G protein-coupled receptor EBI2;
however, the cellular sources of this oxysterol are undefined. 7α,25-OHC is synthesized …