Predicting relapse in Crohn's disease: a biopsychosocial model

…, S Rawal, A Cohen, S Vermeire, L Dufresne… - Gut, 2008 - gut.bmj.com
Background: Crohn’s disease (CD) is a chronic relapsing inflammatory bowel disorder. Both
biological and psychosocial factors may modulate the illness experience. Aim: The aim of …

[PDF][PDF] CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure

…, G Wild, K Kocher, J Cousineau, L Dufresne… - The American Journal of …, 2002 - cell.com
The caspase recruitment domain gene (CARD15) was recently identified as the underlying
gene associated with the IBD1 locus that confers susceptibility to Crohn disease (CD). …

Association of low-density lipoprotein cholesterol–related genetic variants with aortic valve calcium and incident aortic stenosis

…, JC Engert, R Do, G Hindy, G Rukh, L Dufresne… - Jama, 2014 - jamanetwork.com
Importance Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with
aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering …

Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study

…, TW Marsh, SM Damrauer, L Dufresne… - European heart …, 2023 - academic.oup.com
Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains
incompletely understood. The aim of this study was to discover novel genetic contributors to …

Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report

M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp(a) (lipoprotein[a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …

Lipoprotein (a) interactions with low‐density lipoprotein cholesterol and other cardiovascular risk factors in premature acute coronary syndrome (ACS)

M Afshar, L Pilote, L Dufresne, JC Engert… - Journal of the …, 2016 - Am Heart Assoc
Background Current recommendations for lipoprotein(a) (Lp[a]) focus on the control of other
risk factors, including lowering low‐density lipoprotein cholesterol ( LDL ‐C), with little …

Association of LPA variants with aortic stenosis: a large-scale study using diagnostic and procedural codes from electronic health records

HY Chen, L Dufresne, H Burr, A Ambikkumar… - JAMA …, 2018 - jamanetwork.com
Importance Elevated lipoprotein(a) levels are a risk factor for aortic stenosis (AS). However,
a large-scale replication of associations betweenLPAvariants and AS, their interactions with …

Association between family history, a genetic risk score, and severity of coronary artery disease in patients with premature acute coronary syndromes

…, H Al-Lawati, C Labos, L Dufresne… - … , and vascular biology, 2016 - Am Heart Assoc
Objective— A genetic risk score (GRS) for coronary artery disease has recently been shown
to be independent of family history (FHx) in predicting future cardiovascular events. We …

Bioactive scaffolds in stem cell-based therapies for myocardial infarction: a systematic review and Meta-analysis of preclinical trials

K Khan, K Gasbarrino, I Mahmoud, L Dufresne… - Stem Cell Reviews and …, 2022 - Springer
The use of bioactive scaffolds in conjunction with stem cell therapies for cardiac repair after
a myocardial infarction shows significant promise for clinical translation. We performed a …

Association of FADS1/2 locus variants and polyunsaturated fatty acids with aortic stenosis

…, CM Shaffer, J Rong, E Sonestedt, L Dufresne… - JAMA …, 2020 - jamanetwork.com
… Several lines of evidence point to ω-6 fatty acids as possible causal mediators for AS. We
found that a higher ratio of arachidonic acid to linoleic acid (reflecting ω-6 desaturation), but …