Interleukin-1β (IL-1β)-converting enzyme cleaves the IL-1β precursor to mature IL-1β, an
important mediator of inflammation. The identification of the enzyme as a unique cysteine …

The histidyl‐aspartyl phosphorelay, formerly described as the two‐component system, is the
predominant mode of signal transduction in bacteria. Adaptation to environmental changes …

The ompF and ompC genes of Escherichia coli are reciprocally regulated by a single
transcription factor, phosphorylated OmpR (OmpR-P), depending upon medium osmolarity. This …

The major form of IL-1 beta-converting enzyme (ICE) identified in THP.1 monocytic cells and
human monocytes is the 45-kDa precursor protein (p45), which is found in the cytoplasm. …

Directed screening of a carboxylic acid-containing combinatorial library led to the discovery
of potent inhibitors of the integrin VLA-4. Subsequent optimization by solid-phase synthesis …

Nucleoside-diphosphate kinase (NDP kinase), a key enzyme in nucleotide metabolism, is
also known to be involved in growth and developmental control and tumor metastasis …

Background: OmpR is a transcription factor that regulates the expression of the porin genes
ompF and ompC in Escherichia coli. The phosphorylation state of OmpR, directed by the …

A potent, reversible, tetrapeptide inhibitor of interleukin-lβ converting enzyme (ICE), L-709,049,
has been shown to suppress the in vitro production of mature IL-1β. We now report that …

Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify
orally active VLA-4 antagonists was initiated. Herein, we report the discovery of a N-…

We have designed and synthesized a series of heterocyclic bioisosteres for an anilide
based on molecular modeling. Excellent potency was retained in the benzoxazole and the …