Antivascular and antitumor evaluation of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes, a novel series of anticancer agents

…, I Kianicka, D Custeau, C Boudreau, L Geerts… - Molecular cancer …, 2004 - AACR
A novel series of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes was
identified as potent apoptosis inducers through a cell-based high throughput screening assay…

[HTML][HTML] A newly discovered antifibrotic pathway regulated by two fatty acid receptors: GPR40 and GPR84

…, W Gagnon, K Hince, M Tremblay, L Geerts… - The American Journal of …, 2018 - Elsevier
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a
great need for therapies that could effectively target pathophysiological pathways involved in …

[HTML][HTML] Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease

…, L Gervais, A Felton, S Letourneau, L Geerts… - Scientific Reports, 2020 - nature.com
Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease and is
associated with metabolic dysregulation. Although G protein-coupled receptor 84 (GPR84) …

PBI-4050 reduces stellate cell activation and liver fibrosis through modulation of intracellular ATP levels and the liver kinase B1/AMP-activated protein kinase …

…, M Leduc, JC Simard, K Hince, L Geerts… - … of Pharmacology and …, 2018 - ASPET
Hepatic fibrosis is a major cause of morbidity and mortality for which there is currently no
effective therapy. We previously showed that 2-(3-pentylphenyl)acetic acid (PBI-4050) is a dual …

Design and Synthesis of New 1, 3, 5‐Trisubstituted Triazines for the Treatment of Cancer and Inflammation

…, JS Duceppe, L Gagnon, B Grouix, L Geerts… - …, 2018 - Wiley Online Library
Low‐molecular‐weight synthetic molecules 1 with the general 2‐(fluorophenylamino)‐4,6‐disubstituted
1,3,5‐triazine structure and showing anti‐inflammatory and anticancer activities …

Oral treatment with PBI-4050 reduces plasminogen activator inhibitor-1 (PAI-1), alpha-smooth muscle actin (α-SMA) and collagen expression in human fibroblasts and …

…, A Laverdure, W Gagnon, L Geerts… - C74. MODELS AND …, 2016 - atsjournals.org
: PBI-4050 is a first-in-class novel orally active compound which displays anti-inflammatory/antifibrotic
activities in fibrosis Rationale models in different organs: kidney, heart, liver, …

Oral Treatment with PBI-4050 Reduces Acute Lung Injury in an Acute Pancreatitis Model

L Gagnon, L Geerts, B Grouix, M Tremblay… - … OF ACUTE LUNG …, 2017 - atsjournals.org
: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis
still represents a substantial Background problem, with a mortality rate in the range of 30-…

Plasminogen Reduces Acute Lung Injury in an Acute Pancreatitis Model

L Gagnon, L Geerts, B Grouix, M Tremblay… - … OF ACUTE LUNG …, 2017 - atsjournals.org
: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis
still represents a substantial Background problem, with a mortality rate in the range of 30-…

Oral Treatment with PBI-4050 Reduces Serum and Lung Anti-Inflammatory/Fibrotic Biomarkers

…, L Gervais, F Sarra-Bournet, L Geerts… - … AND TARGETS IN …, 2016 - atsjournals.org
: PBI-4050 is a first-in-class novel orally active compound which displays anti-inflammatory/antifibrotic
activities in fibrosis Rationale models in different organs: kidney, heart, liver, …

FP445 PBI-4050 PROTECTS AGAINST RENAL AND PANCREATIC FIBROSIS IN TYPE II DIABETES

…, M Tremblay, MP Cloutier, L Geerts… - Nephrology Dialysis …, 2015 - academic.oup.com
Methods: Free-flow micropuncture collections, from middle proximal convoluted tubules to
late distal tubules in anaesthetized rats is used to assess directly the effect of saccharin on …