User profiles for Leaf Huang
 | Leaf HuangProfessor Emeritus, University of North Carolina at Chapel Hill Verified email at email.unc.edu Cited by 82460 |
[HTML][HTML] Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy
Targeted delivery of RNA-based therapeutics for cancer therapy remains a challenge. We
have developed a LPH (liposome-polycation-hyaluronic acid) nanoparticle formulation …
have developed a LPH (liposome-polycation-hyaluronic acid) nanoparticle formulation …
Nonviral vectors in the new millennium: delivery barriers in gene transfer
M Nishikawa, L Huang - Human gene therapy, 2001 - liebertpub.com
Development of an efficient method for introducing a therapeutic gene into target cells in
vivo is the key issue in treating genetic and acquired diseases by gene therapy. To this end, …
vivo is the key issue in treating genetic and acquired diseases by gene therapy. To this end, …
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol succinyl)phosphotidylethanolamine
(PEG-PE) into large unilamellar liposomes composed of egg posphatidylcholine:…
(PEG-PE) into large unilamellar liposomes composed of egg posphatidylcholine:…
Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.
Direct gene transfer offers the potential to introduce DNA encoding therapeutic proteins to
treat human disease. Previously, gene transfer in humans has been achieved by a cell-…
treat human disease. Previously, gene transfer in humans has been achieved by a cell-…
Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly (ethylene glycol)-containing liposomes
…, AMJ Buiting, N van Rooijen, L Huang - Biochimica et Biophysica …, 1994 - Elsevier
Liposomes containing dioleoyl -N-( monomethoxypoly (ethylene glycol)succinyl)-phosphatidylethanolamine
(PEG-PE), and of three characteristic sizes ( d > 300 nm , d ∼ 150–200 nm , …
(PEG-PE), and of three characteristic sizes ( d > 300 nm , d ∼ 150–200 nm , …
Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
A lipid coated calcium phosphate (LCP) nanoparticle (NP) formulation was developed for
efficient delivery of small interfering RNA (siRNA) to a xenograft tumor model by intravenous …
efficient delivery of small interfering RNA (siRNA) to a xenograft tumor model by intravenous …
Pharmacokinetics and biodistribution of nanoparticles
Nanoparticles show their promise for improving the efficacy of drugs with a narrow therapeutic
window or low bioavailability, such as anticancer drugs and nucleic acid-based drugs. …
window or low bioavailability, such as anticancer drugs and nucleic acid-based drugs. …
Recent advances in nonviral vectors for gene delivery
X Guo, L Huang - Accounts of chemical research, 2012 - ACS Publications
Gene therapy has long been regarded a promising treatment for many diseases, whether
acquired (such as AIDS or cancer) or inherited through a genetic disorder. A drug based on a …
acquired (such as AIDS or cancer) or inherited through a genetic disorder. A drug based on a …
A novel cationic liposome reagent for efficient transfection of mammalian cells
A novel cationic derivative of cholesterol, 3β[N-(N′,N′-dimethylaminoethane)-carbamoyl]
cholesterol (DC-Chol), has been synthesized and used to prepare sonicated liposomes with …
cholesterol (DC-Chol), has been synthesized and used to prepare sonicated liposomes with …
The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer
H Farhood, N Serbina, L Huang - Biochimica et Biophysica Acta (BBA) …, 1995 - Elsevier
In a reporter gene assay, cationic liposomes containing the cationic lipid 3β-(N-(N′,N′-dimethylaminoethane)carbamoyl)cholesterol
(DC-Chol) and a neutral phospholipid …
(DC-Chol) and a neutral phospholipid …