Brain lesions in an infant rhesus monkey treated with monosodium glutamate

JW Olney, LG Sharpe - Science, 1969 - science.org
In an infant rhesus monkey brain damage resulted from subcutaneously administered
monosodium glutamate. Although a relatively high dose of monosodium glutamate was used, the …

Central noradrenergic regulation of cerebral blood flow and vascular permeability.

…, JO Eichling, LG Sharpe - Proceedings of the …, 1975 - National Acad Sciences
Anatomical studies employing the immunofluorescence localization of dopamine-beta-hydroxylase
[= dopamine beta-monooxygenase; 3,4-dihydroxyphenylethylamine, ascorbate:…

Glutamate-induced brain damage in infant primates

JW Olney, LG Sharpe, RD Feigin - Journal of Neuropathology & …, 1972 - academic.oup.com
The brains of 9 infant rhesus monkeys were examined for acute cytopathology following
treatment with monosodium L-glutamate (MSG) (6 infants) or NaCl (3 infants). Hypothalamie …

κ-Opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine

…, JB Justice, RA Vaughan, LG Sharpe… - Journal of …, 2000 - Soc Neuroscience
Coadministration of κ-opioid receptor agonists (κ-agonists) with cocaine prevents alterations
in dialysate dopamine (DA) concentration in the nucleus accumbens (Acb) that occur during …

Social roles in a rhesus monkey group

IS Bernstein, LG Sharpe - Behaviour, 1966 - brill.com
A group of eleven rhesus monkeys selected to approximate a small natural group were
allowed to establish a social organization and to live with minimal disturbance in a specially …

Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat

LG Sharpe, JE Garnett, TJ Cicero - Behavioral biology, 1974 - Elsevier
A total of 137 microinjections of morphine sulfate in doses of 1.0–50 μg were made into
various midbrain sites of 47 rats implanted with chronic indwelling cannulae. Three to six μg of …

Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression

…, LL Miner, MP Perry, RS Revay, LG Sharpe… - Molecular brain …, 1999 - Elsevier
Polygenic factors play important roles in animal models of substance abuse and susceptibility
to dopaminergic neurodegeneration. Genetic factors are also likely to contribute to the …

Preferential responses of young chimpanzees to food and social rewards

WA Mason, SV Saxon, LG Sharpe - The Psychological Record, 1963 - Springer
Three young chimpanzees were permitted to choose between social rewards presented by
humans and food. In the first experiment the independent variables were type of social …

Persistent antagonism of methamphetamine-induced dopamine release in rats pretreated with GBR12909 decanoate

MH Baumann, MA Ayestas, LG Sharpe, DB Lewis… - … of Pharmacology and …, 2002 - ASPET
Methamphetamine abuse is a serious global health problem, and no effective treatments for
methamphetamine dependence have been developed. In animals, the addictive properties …

Withdrawal of repeated cocaine decreases autoradlographic [3H] mazindol-labelling of dopamine transporter In rat nucleus aecumbens

LG Sharpe, NS Pilotte, WM Mitchell… - European journal of …, 1991 - Elsevier
The in vitro autoradiographic distribution of desipramine-insensitive specific [ 3 H]mazindol
binding sites (labelling the dopamine transporter) was determined in brain sections from rats …