Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells
…, O Meurette, O Sergent, G LeMoigne-Muller, L Vernhet… - Cancer research, 2007 - AACR
We have previously shown that cisplatin triggers an early acid sphingomyelinase (aSMase)-dependent
ceramide generation concomitantly with an increase in membrane fluidity and …
ceramide generation concomitantly with an increase in membrane fluidity and …
Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and …
…, C Morzadec, N Allain, O Fardel, L Vernhet - Free Radical Biology …, 2004 - Elsevier
Cadmium-induced cellular toxicity has been related to necrosis and/or caspase-dependent
apoptosis. In the present study, we show that, on cadmium exposure, the human …
apoptosis. In the present study, we show that, on cadmium exposure, the human …
Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: perspectives for scleroderma-associated interstitial lung …
…, A Ballerie, S Jouneau, P Jego, L Vernhet… - Biochemical …, 2020 - Elsevier
Janus kinase (JAK) inhibitors (also termed Jakinibs) constitute a family of small drugs that
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They exert …
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They exert …
Human macrophages constitute targets for immunotoxic inorganic arsenic
…, E Bourdonnay, O Fardel, L Vernhet - The Journal of …, 2006 - journals.aai.org
Chronic exposure to inorganic arsenic, a widely distributed environmental contaminant, can
lead to toxic effects, including immunosuppression. Owing to the established roles of human …
lead to toxic effects, including immunosuppression. Owing to the established roles of human …
[HTML][HTML] Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis
…, B Crestani, R Thibault, M Lederlin, L Vernhet… - Respiratory …, 2020 - Springer
Background Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some
patients treated with nintedanib experience weight loss. Exploratory data suggest that low …
patients treated with nintedanib experience weight loss. Exploratory data suggest that low …
Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-κB-related survival pathway down-regulation
Arsenic trioxide (As 2 O 3 ) is known to be toxic toward leukemia cells. In this study, we
determined its effects on survival of human monocytic cells during macrophagic differentiation, an …
determined its effects on survival of human monocytic cells during macrophagic differentiation, an …
Alteration of human macrophage phenotypes by the anti-fibrotic drug nintedanib
…, V Lecureur, L Wollin, S Jouneau, L Vernhet - International …, 2019 - Elsevier
The tyrosine kinase inhibitor, Nintedanib (NTD), has been approved for the treatment of
idiopathic pulmonary fibrosis (IPF). In cell-free systems, NTD was recently shown to inhibit …
idiopathic pulmonary fibrosis (IPF). In cell-free systems, NTD was recently shown to inhibit …
[HTML][HTML] Distinct properties of human M-CSF and GM-CSF monocyte-derived macrophages to simulate pathological lung conditions in vitro: application to systemic …
…, Y Augagneur, C Morzadec, L Vernhet… - International journal of …, 2018 - mdpi.com
Macrophages play a central role in the pathogenesis of inflammatory and fibrotic lung diseases.
However, alveolar macrophages (AM) are poorly available in humans to perform in vitro …
However, alveolar macrophages (AM) are poorly available in humans to perform in vitro …
[HTML][HTML] Crystalline silica impairs efferocytosis abilities of human and mouse macrophages: implication for silica-associated systemic sclerosis
…, S Jouneau, P Jégo, O Fardel, L Vernhet… - Frontiers in …, 2020 - frontiersin.org
Inhalation of crystalline silica (SiO 2 ) is a risk factor of systemic autoimmune diseases such
as systemic sclerosis (SSc) and fibrotic pulmonary disorders such as silicosis. A defect of …
as systemic sclerosis (SSc) and fibrotic pulmonary disorders such as silicosis. A defect of …
Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone
…, S Kerdine-Römer, O Fardel, L Vernhet - Free Radical Biology …, 2014 - Elsevier
The transcription factor nuclear factor-erythroid 2-related-2 (Nrf2) controls cellular redox
homeostasis and displays immunomodulatory properties. Nrf2 alters cytokine expression in …
homeostasis and displays immunomodulatory properties. Nrf2 alters cytokine expression in …