Docetaxel (Taxotere®), a semi-synthetic analog of paclitaxel (Taxol®), is a promoter of
microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity. …

We have investigated the conversion of the novel anti-topoisomerase I agent CPT-11 (irinotecan;
7-ethyl-10[4-(1-piperidino)-1piperidino]carbonyloxycamptothecin) to its active …

An important limitation in the use of chemotherapy in cancer treatment is that cytotoxic
agents have small margins of safety compared with other drugs. The largely unpredictable …

The fenestrated sinusoidal endothelium (‘liver sieve’) and space of Disse in the healthy liver
do not impede the transfer of most substrates, including drugs and oxygen, from the …

Irinotecan (CPT-11) is an analogue of 20(S)-camptothecin with promising activity against
several tumor types. In patients, CPT-11 is metabolized to 7-ethyl-10-hydroxycamptothecin (SN-…

Depletion of nutritional reserves and significant weight loss can lead to an increased risk of
morbidity, reduced chemotherapy response, and shorter survival in patients with cancer. …

Purpose: To evaluate the effect of thymidylate synthase (TYMS) and methylenetetrahydrofolate
reductase (MTHFR) genotypes on toxicity in patients treated with capecitabine for …

Purpose: The purpose is to identify the demographic, physiologic, and inheritable factors that
influence CYP3A activity in cancer patients Experimental Design: A total of 134 patients (62 …

Irinotecan, or CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine),
is a water-soluble derivative of camptothecine with promising activity against several types …

The discovery of the plant alkaloid 20(S)camptothecin (CPT), which displayed potent
antitumor activity in preclinical trials, has led to the identification of a novel target of cancer …