Enkephalin may mediate euphoria and drive-reduction reward
JD Belluzzi, L Stein - Nature, 1977 - nature.com
THE identification in brain of opiate receptors 1 and morphine-like pentapeptides (methionine-enkephalin
and leucine-enkephalin) 2 has led to suggestions that enkephalin receptors …
and leucine-enkephalin) 2 has led to suggestions that enkephalin receptors …
Benzodiazepines: anxiety-reducing activity by reduction of serotonin turnover in the brain
CD Wise, BD Berger, L Stein - Science, 1972 - science.org
The anxiety-reducing effects of minor tranquilizers in the rat conflict test were mimicked by
serotonin antagonists and by p-chlorophenylalanine, an inhibitor of serotonin synthesis; the …
serotonin antagonists and by p-chlorophenylalanine, an inhibitor of serotonin synthesis; the …
Analgesia induced in vivo by central administration of enkephalin in rat
…, N Grant, V Garsky, D Sarantakis, CD Wise, L Stein - Nature, 1976 - nature.com
ENKEPHALIN, a natural opiate receptor agonist in brain 1–4 , has been identified by
Hughes et al. as a mixture of two pentapeptides : H–Tyr–Gly–Gly–Phe–Met–OH (methionine–…
Hughes et al. as a mixture of two pentapeptides : H–Tyr–Gly–Gly–Phe–Met–OH (methionine–…
Possible etiology of schizophrenia: Progressive damage to the noradrenergic reward system by 6-hydroxydopamine
L Stein, CD Wise - Science, 1971 - science.org
Single or repeated intraventricular injections of 6-hydroxydopamine caused marked and
long-lasting deficits in brain self-stimulation and other rewarded behaviors in the rat. The …
long-lasting deficits in brain self-stimulation and other rewarded behaviors in the rat. The …
The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system
With the indirect immunofluorescence technique the distribution of methionine-enkephalin-immunoreactive
cell bodies was studied in the central nervous system of rats pretreated with …
cell bodies was studied in the central nervous system of rats pretreated with …
The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats
DW Self, L Stein - Brain research, 1992 - Elsevier
The reported failure of the prototypical (but partial) D 1 agonist SKF 38393 to support self-administration
behavior contradicts hypotheses of D 1 -mediated reinforcement. Here we …
behavior contradicts hypotheses of D 1 -mediated reinforcement. Here we …
Release of norepinephrine from hypothalamus and amygdala by rewarding medial forebrain bundle stimulation and amphetamine.
L Stein, CD Wise - Journal of comparative and physiological …, 1969 - psycnet.apa.org
The hypothalamus and amygdala of 76 unanesthetized rats were perfused with Locke's
solution through a permanently indwelling push-pull cannula after intraventricular injection of a …
solution through a permanently indwelling push-pull cannula after intraventricular injection of a …
Dopamine-β-hydroxylase deficits in the brains of schizophrenic patients
CD Wise, L Stein - Science, 1973 - science.org
Postmortem brain specimens from 18 schizophrenic patients and 12 normal controls were
assayed for dopamine-β-hydroxylase (DBH), the enzyme responsible for the final step in …
assayed for dopamine-β-hydroxylase (DBH), the enzyme responsible for the final step in …
Effects and interactions of imipramine, chlorpromazine, reserpine and amphetamine on self-stimulation: possible neurophysiological basis of depression
L Stein, HE Himwich - Recent Advances in Biological Psychiatry: Volume …, 1962 - Springer
Neural theorizing about the affective disorders has been given substance by recent
discoveries of brain systems for positive and negative reinforcement. Brain loci for negative …
discoveries of brain systems for positive and negative reinforcement. Brain loci for negative …
Some effects of two temporal variables on conditioned suppression
METHOD Subjects Five male albino rats, approximately 90 days old at the start of the
experiment. Apparatus The experimental space was a metal chamber with a lever in one wall, …
experiment. Apparatus The experimental space was a metal chamber with a lever in one wall, …