The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding
of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at …

Low-dose radiation reprogrammed the tumor microenvironment of tumors with scarce immune
infiltration and together with immunotherapy induced simultaneous mobilization of innate …

We investigated the role of chemokines in regulating T cell accumulation in solid tumors.
CCL5 and CXCL9 overexpression was associated with CD8 + T cell infiltration in solid tumors. …

We conducted a pilot clinical trial testing a personalized vaccine generated by autologous
dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC), which …

Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient populations. …

… A study demonstrated that the use of vitamin E supplement was able to reconstitute
immunological … Lana E. Kandalaft provided the outline and discussion points; provided ideas for …

The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a
central role in our ability to understand and predict (neo-)antigen presentation in infectious …

Purpose: Whole tumor lysates are promising antigen sources for dendritic cell (DC) therapy
as they contain many relevant immunogenic epitopes to help prevent tumor escape. Two …

The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we show that …

The success of cancer immunotherapy depends in part on the strength of antigen recognition
by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) …