Purpose Pazopanib, an oral angiogenesis inhibitor, is approved for the treatment of
advanced renal cell carcinoma (RCC). Response to pazopanib monotherapy varies between …

Mutations in the leucine‐rich repeat kinase‐2 gene (LRRK2) are responsible for some forms
of familial as well as sporadic Parkinson's disease (PD). The purpose of this study was to …

Background HLA-B*57:01 screening was added to clinical care guidelines in 2008 to reduce
the risk of hypersensitivity reaction from abacavir. The uptake of HLA-B*57:01 screening …

Background Some observational studies and randomized controlled trials (RCTs) have
suggested an association between abacavir (ABC) use and myocardial infarction (MI), whereas …

Since 1987 Perkin sus marinus has been the most important pathogen of the eastern oyster,
Crassostrea virginica, in Chesapeake Bay because of its widespread distribution and …

The effect of salinity on Perkinsus marinus, a protozoan pathogen of the eastern oyster,
Crassostrea virginica (Gmelin 1791) was investigated. Oysters parasitized by P. marinus were …

… peaks of the Ba L family), S (a single SK peak), and Sr (a single Sr L peak). The peak at
1.81 keV was identified as Sr L, rather than Si K (1.74 keV), based not only on a detailed …

Background Pretreatment and acquired drug resistance mutations (DRMs) can limit
antiretroviral therapy effectiveness. Methods We review prevalence of DRMs with resistance to …

The purpose of the present study was to verify the acute effect of sodium bicarbonate
supplementation on symptoms of gastrointestinal discomfort, acid-base balance and intermittent …

Adenosine-to-inosine editing in the anticodon of tRNAs is essential for viability. Enzymes
mediating tRNA adenosine deamination in bacteria and yeast contain cytidine deaminase-…