Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that plays a role in
the modulation of food intake and mood. In rodents, the actions of MCH are mediated via the …

Dual inhibition of angiotensin-converting enzyme (ACE) and neprilysin (NEP) by drugs such
as omapatrilat produces superior antihypertensive efficacy but cause high incidence of …

The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally
linked to Parkinson’s disease (PD), a disabling and progressive neurodegenerative disorder …

Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation
of Th17 differentiation and function. RORγT was initially identified as a transcription factor …

Genetic mutation of the leucine-rich repeat kinase 2 (LRRK2) protein has been associated
with Parkinson’s disease (PD), a disabling and progressive neurodegenerative disorder that …

Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have
been approved for treatment of ulcerative colitis with several other JAK inhibitors in late-stage …

Inhibition of leucine-rich repeat kinase 2 (LRRK2) kinase activity represents a genetically
supported, chemically tractable, and potentially disease-modifying mechanism to treat …

Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y 1 , Y 2 ,
Y 4 , Y 5 , and y 6 ). The Y 5 receptor is well known for its role in appetite. Based on …

Despite much effort over recent years to design and develop endothelin-receptor antagonists,
these compounds are far from becoming new drug entities. This article will review …

Melanin-concentrating hormone (MCH) is an orexigenic and dipsogenic neuropeptide that
has been reported to mediate acute behavioral and neuroendocrine stress-related responses …