The brain neuronal systems defined by the neurotransmitter dopamine (DA) have since long
a recognized role in the regulation of motor functions. More recently, converging evidence …

Positron emission tomography (PET) is a non-invasive technology of nuclear medicine that
has sensitivity for tracing low picomolar concentrations of radiolabeled molecules in the …

Antipsychotic drugs were introduced in the early 50s on the basis of clinical observations in
patients with schizophrenia. Experimental studies later revealed that antagonism at the D 2 …

The relationship between central D2-dopamine receptor occupancy and antipsychotic drug
effects was examined in a double-blind study. Raclopride was the compound used to induce …

• Positron emission tomography and selective radioligands were used to determine D , and
D 2 dopamine receptor occupancy induced by neuroleptics in the basal ganglia of drug-…

Using positron emission tomography and the selective ligands 11 C-SCH23390 and 11 C-raclopride,
central D1- and D2-dopamine receptor occupancy was determined in …

D2 dopamine receptors in the putamen of living human subjects were characterized by using
the selective, high-affinity D2 dopamine receptor antagonist carbon-11-labeled raclopride …

The density of striatal dopamine D2 receptors has been shown to vary considerably among
healthy subjects. 1 This variability might be due to genetic or environmental factors. In the …

• Using positron emission tomography and the carbon 11—labeled ligand raclopride, central
D2-dopamine receptor occupancy in the putamen was determined in psychiatric patients …

OBJECTIVE: The study examined the influence of losses in dopaminergic function on age-related
cognitive deficits. METHOD: Eleven healthy subjects (21–68 years of age) completed …