User profiles for L. V. Hryshko

Larry V Hryshko

Professor of Physiology and Pathophysiology
Verified email at sbrc.ca
Cited by 3619

Cloning of the NCX2 isoform of the plasma membrane Na (+)-Ca2+ exchanger

Z Li, S Matsuoka, LV Hryshko, DA Nicoll… - Journal of Biological …, 1994 - ASBMB
… Sequence analysis suggested that the clone coded for a Na+-Ca2+ exchanger, but the
sequence identity to NCXl at the nucleotide level was only about 65%. This suggested the …

Regulation of the cardiac Na (+)-Ca2+ exchanger by Ca2+. Mutational analysis of the Ca (2+)-binding domain.

S Matsuoka, DA Nicoll, LV Hryshko… - The Journal of general …, 1995 - rupress.org
… In any case, the characteristics of different exchangers did not vary with level of expression.
… We found that the cytoplasmic Na + dependence varied with the level of regulatory Ca 2+. In …

A whole blood–based perfusate provides superior preservation of myocardial function during ex vivo heart perfusion

…, A Ravandi, RC Arora, TW Lee, LV Hryshko… - The Journal of Heart and …, 2015 - Elsevier
Left ventricular function was assessed in working mode at T1, T3, and T5 using a 5F
Ventri-Cath 507 conductance catheter (Millar Inc, Houston, TX). Load-dependent measures were …

[HTML][HTML] Mutation of amino acid residues in the putative transmembrane segments of the cardiac sarcolemmal Na+-Ca2+ exchanger

DA Nicoll, LV Hryshko, S Matsuoka, JS Frank… - Journal of Biological …, 1996 - ASBMB
… , the mutant displayed a moderate level of activity. However, when the glycine was
substituted with a serine, there was a significant reduction in the level of activity. Mutants at this …

Extracellular and intracellular proteases in cardiac dysfunction due to ischemia–reperfusion injury

AL Müller, LV Hryshko, NS Dhalla - International journal of cardiology, 2013 - Elsevier
… Proteases are active at a basal level in cardiomyocytes. However, their actions are controlled
via regulation of their transcription, translation, chaperone molecules, and endogenous …

[HTML][HTML] Physiologic changes in the heart following cessation of mechanical ventilation in a porcine model of donation after circulatory death: implications for cardiac …

…, RC Arora, G Tian, J Nagendran, LV Hryshko… - American Journal of …, 2016 - Elsevier
Hearts donated following circulatory death (DCD) may represent an additional source of
organs for transplantation; however, the impact of donor extubation on the DCD heart has not …

Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury.

C Lee, NS Dhalla, LV Hryshko - The Canadian journal of cardiology, 2005 - europepmc.org
The cardiac Na+-Ca2+ exchanger (NCX) plays an essential role in regulating Ca2+ under
physiological and pathophysiological conditions. In its forward mode of operation, which …

Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences

…, GJ Gross, M Hnatowich, LV Hryshko - American Journal …, 2001 - journals.physiology.org
… were then evaluated in an ischemia-reperfusion model of cardiac injury in Langendorff-perfused
whole rabbit hearts using electrocardiography and measurements of left ventricular

Ionic Regulatory Properties of Brain and Kidney Splice Variants of the Ncx1 Na+–Ca2+ Exchanger

…, KD Philipson, M Hnatowich, LV Hryshko - The Journal of general …, 1999 - rupress.org
… Stroke Foundation of Canada grant to LV Hryshko, and by the National Institutes of Health
grants HL-48509 and HL-49101 (KD Philipson). LV Hryshko is supported by a Scholarship …

Anomalous regulation of the Drosophila Na (+)-Ca2+ exchanger by Ca2+.

LV Hryshko, S Matsuoka, DA Nicoll, JN Weiss… - The Journal of general …, 1996 - rupress.org
… A preliminary report of this work has appeared in abstract form (Hryshko, LV, DA Nicoll, S. …
Hryshko's present address is Division of Cardiovascular Sciences, St. Boniface Hospital …