LPS stimulates monocytes/macrophages through TLR4, resulting in the activation of a series
of signaling events that potentiate the production of inflammatory mediators. Recent reports …

It has long been known that the ITIM-bearing IgG Fc receptor (FcγRIIb, RIIb) is expressed on
liver sinusoidal endothelial cells (LSEC) and that the liver is the major site of small immune …

During Gram-negative bacterial infections, excessive LPS induces inflammation and sepsis
via action on immune cells. However, the bulk of LPS can be cleared from circulation by the …

The liver removes quickly the great bulk of virus circulating in blood, leaving only a small
fraction to infect the host, in a manner characteristic of each virus. The scavenger cells of the …

The bacterial endotoxin lipopolysaccharide (LPS), is a potent inducer of the inflammatory
response. Previous studies demonstrated that LPS-induced toxicity is reversed upon FcγR …

We previously showed that C-phycocyanin (PC), an antioxidant biliprotein pigment of Spirulina
platensis (a blue-green alga), effectively inhibited doxorubicin-induced oxidative stress …

In adults, the nonclassical MHC class I molecule, FcRn, binds both IgG and albumin and
rescues both from a degradative fate, endowing both proteins with high plasma concentrations. …

The Gram-negative bacterium Francisella novicida infects primarily monocytes/macrophages
and is highly virulent in mice. Macrophages respond by producing inflammatory cytokines …

Cholesterol from peripheral tissue, carried by HDL, is metabolized in the liver after uptake
by the HDL receptor, SR-B1. Hepatocytes have long been considered the only liver cells …

The immune pathways that define treatment response and non-response in lupus nephritis (LN)
are unknown. To characterize these intra-kidney pathways, transcriptomic analysis was …