Malformations of cortical development (MCDs) are neurodevelopmental disorders that
result from abnormal development of the cerebral cortex in utero. MCDs place a substantial …

Transcriptional dysregulation in Huntington’s disease (HD) is an early event that shapes the
brain transcriptome by both the depletion and ectopic activation of gene products that …

Huntington’s disease (HD) is a devastating neurodegenerative disorder that is caused by
an abnormal expansion of CAG repeats in the Huntingtin (HTT) gene. Although the main …

Rubinstein-Taybi syndrome (RSTS) is an inheritable disease associated with mutations in
the gene encoding the CREB (cAMP response element-binding protein)-binding protein (CBP…

Long-lasting forms of neuronal plasticity require de novo gene expression, but relatively
little is known about the events that occur genome-wide in response to activity in a neuronal …

The epigenetic changes of the chromatin represent an attractive molecular substrate for
adaptation to the environment. We examined here the role of CREB‐binding protein (CBP), a …

Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent
memory and synaptic plasticity and to ameliorate cognitive deficits and degeneration …

The cAMP-responsive element-binding protein (CREB) pathway has been involved in 2 major
cascades of gene expression regulating neuronal function. The first one presents CREB …

Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of
its proposed causes is defective neuronal histone acetylation, but important aspects of this …

The orexin (OX) system has been implicated in food-reinforced behavior, food-seeking and
food overconsumption. Recent evidence suggests that OX signaling might influence …