The role of the ubiquitin-dependent proteolysis system in c-Jun breakdown was investigated.
Using in vitro experiments and a novel in vivo assay that utilizes molecularly-tagged …

Retinoic acid and thyroid hormone receptors can act alternatively as ligand-independent
repressors or ligand-dependent activators, based on an exchange of N-CoR or SMRT-…

Acetylation and deacetylation of nucleosomal histones have profound effects on gene
transcription in all eukaryotes. In humans, three highly homologous class I and four class II histone …

Drosophila Jun is shown to be involved in different signal transduction pathways and
developmental decisions. Dorsal closure, a morphogenetic process occurring during Drosophila …

The expression of the D. melanogaster transcription factor Jun in the eye imaginal disc
correlates temporally and spatially with the determination of neuronal photoreceptor fate. …

Drosophila Jun (D‐Jun) is a nuclear component of the receptor tyrosine kinase/Ras signal
transduction pathway which triggers photoreceptor differentiation during eye development. …

PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation
associated with dry eye. Disclosed herein is the development of a novel series of water-…

Nitric oxide (NO) derived from neuronal nitric-oxide synthase (nNOS) and inducible nitric-oxide
synthase (iNOS) plays a key role in various pain and inflammatory states. KLYP961 (4-((2…

Alzheimer's disease-associated presenilins 1 and 2 (PS1 and PS2) have recently been
identified as two multimembranespanning proteins. Mutations in their respective genes cause …

… To confirm that these Nbs1 signals mark DSBs, we performed LM-PCR using primers within
… Also, by LM-PCR we detect a comparable low frequency of DSBs in the c-myc locus in both …