Substantial evidence now exists to support that formation of DNA G-quadruplexes (G4s) is
coupled to altered gene expression. However, approaches that allow us to probe G4s in living …

Protein misfolding and aggregation is the hallmark of numerous human disorders, including
Alzheimer’s disease. This process involves the formation of transient and heterogeneous …

Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate
mineralization of bone and the vasculature has devastating effects on patient health, yet an …

Neurodegenerative diseases such as Alzheimer's and Parkinson's are associated with
protein misfolding and aggregation. Recent studies suggest that the small, rare and …

Hexagonal boron nitride (h-BN) is a 2D, wide band gap semiconductor that has recently
been shown to display bright room-temperature emission in the visible region, sparking …

TREM2 is a pattern recognition receptor, expressed on microglia and myeloid cells, detecting
lipids and Aβ and inducing an innate immune response. Missense mutations (eg, R47H) of …

To understand how the nucleosome remodeling and deacetylase (NuRD) complex regulates
enhancers and enhancer–promoter interactions, we have developed an approach to …

Fluorescent nucleobase surrogates capable of Watson–Crick hydrogen bonding are
essential probes of nucleic acid structure and dynamics, but their limited brightness and short …

A major challenge in single-molecule imaging is tracking the dynamics of proteins or
complexes for long periods of time in the dense environments found in living cells. Here, we …

The benzothiazolium salt, Thioflavin T (ThT), has been widely adopted as the “gold-standard”
fluorescent reporter of amyloid in vitro. Its properties as a molecular rotor result in a large-…