Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress
…, J Gerard, A Harutyunyan, SM Hool, LL Susick… - Behavioural Brain …, 2016 - Elsevier
Appropriate animal models of posttraumatic stress disorder (PTSD) are needed because
human studies remain limited in their ability to probe the underlying neurobiology of PTSD. …
human studies remain limited in their ability to probe the underlying neurobiology of PTSD. …
Experimental traumatic brain injury alters ethanol consumption and sensitivity
JL Lowing, LL Susick, JP Caruso… - Journal of …, 2014 - liebertpub.com
Altered alcohol consumption patterns after traumatic brain injury (TBI) can lead to significant
impairments in TBI recovery. Few preclinical models have been used to examine alcohol …
impairments in TBI recovery. Few preclinical models have been used to examine alcohol …
Deficits in behavioral sensitization and dopaminergic responses to methamphetamine in adenylyl cyclase 1/8‐deficient mice
KE Bosse, JL Charlton, LL Susick… - Journal of …, 2015 - Wiley Online Library
The cAMP /protein kinase A pathway regulates methamphetamine ( METH )‐induced
neuroplasticity underlying behavioral sensitization. We hypothesize that adenylyl cyclases ( AC ) 1/…
neuroplasticity underlying behavioral sensitization. We hypothesize that adenylyl cyclases ( AC ) 1/…
Postnatal ethanol exposure simplifies the dendritic morphology of medium spiny neurons independently of adenylyl cyclase 1 and 8 activity in mice
LL Susick, JL Lowing, AM Provenzano… - Alcoholism: Clinical …, 2014 - Wiley Online Library
Background Fetal exposure to alcohol can have multiple deleterious effects, including
learning disorders and behavioral and executive functioning abnormalities, collectively termed …
learning disorders and behavioral and executive functioning abnormalities, collectively termed …
Investigation of calcium-stimulated adenylyl cyclases 1 and 8 on toluene and ethanol neurobehavioral actions
The abused inhalant toluene has potent behavioral effects, but only recently has progress
been made in understanding the molecular pathways that mediate the action of toluene in the …
been made in understanding the molecular pathways that mediate the action of toluene in the …
Adenylyl cyclase 1 is required for ethanol-induced locomotor sensitization and associated increases in NMDA receptor phosphorylation and function in the dorsal …
KE Bosse, MF Oginsky, LL Susick… - … of Pharmacology and …, 2017 - ASPET
… Part of this work was presented as follows: Bosse KE, Susick LL, Ramalingam S, and
Conti AC (2015) Role for adenylyl cyclase 1 in ethanol-mediated locomotor sensitization and …
Conti AC (2015) Role for adenylyl cyclase 1 in ethanol-mediated locomotor sensitization and …
[HTML][HTML] Impaired ethanol-induced sensitization and decreased cannabinoid receptor-1 in a model of posttraumatic stress disorder
JJ Matchynski-Franks, LL Susick, BL Schneider… - PLoS …, 2016 - journals.plos.org
Background and Purpose Impaired striatal neuroplasticity may underlie increased alcoholism
documented in those with posttraumatic stress disorder (PTSD). Cannabinoid receptor-1 (…
documented in those with posttraumatic stress disorder (PTSD). Cannabinoid receptor-1 (…
[HTML][HTML] Calcium/calmodulin-stimulated adenylyl cyclases 1 and 8 regulate reward-related brain activity and ethanol consumption
…, AT Eapen, JL Charlton, LL Susick… - Brain imaging and …, 2019 - Springer
Evidence suggests a predictive link between elevated basal activity within reward-related
networks (eg, cortico-basal ganglia-thalamic networks) and vulnerability for alcoholism. Both …
networks (eg, cortico-basal ganglia-thalamic networks) and vulnerability for alcoholism. Both …
Adenylyl cylases 1 and 8 mediate select striatal-dependent behaviors and sensitivity to ethanol stimulation in the adolescent period following acute neonatal ethanol …
LL Susick, JL Lowing, KE Bosse, CC Hildebrandt… - Behavioural brain …, 2014 - Elsevier
Neonatal alcohol exposure in rodents causes dramatic neurodegenerative effects throughout
the developing nervous system, particularly in the striatum, acutely after exposure. These …
the developing nervous system, particularly in the striatum, acutely after exposure. These …
Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder
LL Susick, AC Chrumka, SM Hool, AC Conti - Alcohol, 2016 - Elsevier
Brain-derived neurotrophic factor (BDNF) mediates neuron growth and is regulated by
adenylyl cyclases (ACs). Mice lacking AC1/8 (DKO) have a basal reduction in the dendritic …
adenylyl cyclases (ACs). Mice lacking AC1/8 (DKO) have a basal reduction in the dendritic …