The kidneys compose approximately 0.5 % of the body mass but consume about 10 % of the
oxygen in cellular respiration. This discordance is due to the high energy demands on the …

Mitochondrial biogenesis may be an adaptive response necessary for meeting the increased
metabolic and energy demands during organ recovery after acute injury, and renal …

Acute kidney injury (AKI) is a disease with mitochondrial dysfunction and a newly established
risk factor for the development of chronic kidney disease (CKD) and fibrosis. We examined …

A critical step in the transformation of cells to the malignant state of cancer is the induction of
mutations in the DNA of cells damaged by genotoxic agents. Translesion DNA synthesis (…

Recent studies show the importance of mitochondrial dysfunction in the initiation and
progression of acute kidney injury (AKI). However, no biomarkers exist linking renal injury to …

Recent studies demonstrate that mitochondrial dysfunction is a mediator of acute kidney
injury (AKI). Consequently, restoration of mitochondrial function after AKI may be key to the …

Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely accepted
pathophysiologic feature of sepsis-induced acute kidney injury (AKI), the molecular …

While disruption of energy production is an important contributor to renal injury, metabolic
alterations in sepsis-induced AKI remain understudied. We assessed changes in renal cortical …

Circulating tumor cells (CTC) are cells that have detached from primary tumors and circulate
in the bloodstream where they are carried to other organs, leading to seeding of new tumors …

Background Robenacoxib (Onsior™) is a non-steroidal anti-inflammatory drug developed for
canine and feline use for the control of pain and inflammation. It is available as both tablets …