A major development of carcinogenesis research in the past 20 years has been the discovery
of significant levels of DNA damage arising from endogenous cellular sources. Dramatic …

… Research in the Marnett laboratory is supported by research and center grants from the … PC
Dedon, JP Plastaras, CA Rouzer, LJ Marnett, Indirect mutagenesis by oxidative DNA damage…

… that contained no detectable oligomeric impurities (Basu and Marnett, 1983). The dimer of
MDA … Research in the Marnett laboratory is supported by research and center grants from the …

The presence and function of CB 2 receptors in central nervous system (CNS) neurons are
controversial. We report the expression of CB 2 receptor messenger RNA and protein …

Oxidation products of lipids, proteins, and DNA in the blood, plasma, and urine of rats were
measured as part of a comprehensive, multilaboratory validation study searching for …

Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in
rodents. In view of the sparse information on the pharmacodynamics and pharmacokinetics …

Malondialdehyde (MDA) is an endogenous genotoxic product of enzymatic and oxygen
radical-induced lipid peroxidation whose adducts are known to exist in DNA isolated from …

Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two
steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 …

… NP and Marnett, LJ. unpublished data). This result implies that Ash lcj can be glycosylated.
… are also glycosylated (Bienkowski, MJ and Marnett, LJ, unpublished datal. Early studies on …

Prostaglandins were discovered in human semen in 1930, but their low concentrations and
instability precluded identification for nearly 30 years (for a brief historical review, see Ref. 1). …